Evidence map›Paper›PMID 35363082›Full record

ReviewToxicologic pathology2022

Common and Not-So-Common Pathologic Findings of the Gastrointestinal Tract of Rhesus and Cynomolgus Macaques.

Amanda L Johnson, Rebekah I Keesler, Anne D Lewis, J Rachel Reader, Steven T Laing

Abstract readReview
In one paragraph

Review in Toxicologic pathology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
  2. Article
  3. A review of chronic enterocolitis of rhesus macaques (Frontiers in veterinary science · 2026
    Review
  4. Article
  5. Article
  6. Veterinary sciences · 2025
    Review
  7. Diversity ofmSphere · 2024
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc · 2023
    Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Amanda L JohnsonOregon National Primate Research Center, Beaverton, Oregon, USA.
Rebekah I KeeslerCharles River Laboratories, Reno, Nevada, USA.
Anne D LewisOregon National Primate Research Center, Beaverton, Oregon, USA.ORCID 0000-0003-4059-7318
J Rachel ReaderCalifornia National Primate Research Center, Davis, California, USA.
Steven T LaingGenentech Ltd., South San Francisco, California, USA.ORCID 0000-0002-6079-3095

Funding

Upgrade of confocal microscopy at the Oregon National Primate Research CenterP51OD011092 · OD · OREGON HEALTH & SCIENCE UNIVERSITY · PI Bonnie J. Nagel · 2012 to 2026
$203.9M
National Institute on Aging (NIA) ColonyP51OD011107 · OD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Simon J. Atkinson · 2012 to 2026
$191.5M
Slide Scanner for the ONPRC Imaging and Morphology CoreS10OD025002 · OD · OREGON HEALTH & SCIENCE UNIVERSITY · PI SRINIVASAN, SATHYA · 2018 to 2018
$146k
NIH HHS P51 OD011092NIH HHS P51 OD011107NIH HHS S10 OD025002
6 · The paper itself

Abstract

Rhesus and cynomolgus macaques are the most frequently used nonhuman primate (NHP) species for biomedical research and toxicology studies of novel therapeutics. In recent years, there has been a shortage of laboratory macaques due to a variety of competing factors. This was most recently exacerbated by the surge in NHP research required to address the severe acute respiratory syndrome (SARS)-coronavirus 2 pandemic. Continued support of these important studies has required the use of more varied cohorts of macaques, including animals with different origins, increased exposure to naturally occurring pathogens, and a wider age range. Diarrhea and diseases of the gastrointestinal tract are the most frequently occurring spontaneous findings in macaques of all origins and ages. The purpose of this review is to alert pathologists and scientists involved in NHP research to these findings and their impact on animal health and study endpoints, which may otherwise confound the interpretation of data generated using macaques.

Indexed as

COVID-19AnimalsGastrointestinal TractMacaca fascicularisMacaca mulattadiagnostic pathologydiarrheadigestive systemmacaqueprimate pathology

Identifiers

PMID35363082
PMCPMC9308647

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.