ArticleSpine deformity2022
Marfan syndrome and adolescent idiopathic scoliosis patients have similar 90-day postoperative outcomes and 5-year reoperation rates after spinal deformity surgery.
Article in Spine deformity, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 17 citations in OpenAlex.
- Pediatric patients with arthrogryposis have increased early complications and long-term reoperation risk following posterior spinal fusion.Spine deformity · 2026Article
- Following posterior spinal fusion for adolescent idiopathic scoliosis, patients with asthma are at increased odds of pulmonary adverse events.North American Spine Society journal · 2026Article
- Postoperative complications after anterior cervical discectomy and fusion in patients with versus without carotid artery stenosis.North American Spine Society journal · 2026Article
- Sleep apnea increases odds of 90-day postoperative complications and healthcare utilization following lumbar discectomy.North American Spine Society journal · 2025Article
- Outcomes following single level posterior lumbar fusion in patients with systemic and discoid lupus: A retrospective national database study.North American Spine Society journal · 2025Article
- Patients with fibromyalgia have increased risk of 90-day postoperative adverse events following arthroscopic rotator cuff repair.JSES international · 2025Article
- Patients with achondroplasia have increased risk of 90-day adverse events following laminectomy: A matched comparison using a national database.Spine deformity · 2025Article
- Risk Factors for Perioperative Nerve Injury Related to Total Hip Arthroplasty.Arthroplasty today · 2024Article
- A 10-year perspective on the question of whether surgeries for adolescent idiopathic scoliosis are "one and done"?Spine deformity · 2024Review
- Cefazolin Alone Versus Cefazolin with Tobramycin or Gentamicin as Intraoperative Antibiotic Prophylaxis for Single-Level Posterior Lumbar Fusion.Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews · 2024Article
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Authors and funding
7 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
purposeOutcomes after spinal deformity surgery in patients with Marfan syndrome (MFS) are poorly characterized given the rarity of the condition. Updated analyses from nationally representative samples, and comparison to outcomes after more commonly performed procedures for conditions such as adolescent idiopathic scoliosis (AIS) could help define the relative risks.
methodsUsing the 2010-2020 PearlDiver administrative databases, patients who underwent posterior spinal fusion for > 7 segments were extracted. MFS patients were matched 1:4 to AIS patients based on age, sex, and Elixhauer comorbidity index (ECI). Ninety-day outcomes and 5-year reoperation rates were compared. Significance was set at p < 0.05.
resultsIn total, 206 MFS patients were matched to 825 AIS patients. After adjusting for age, sex, and ECI, multivariate odds ratios (OR) for 90-day any, serious, and minor adverse events, as well as readmissions, were not significantly different for those with MFS compared to those with AIS (p > 0.05 for each). Five-year reoperation rates were also not significantly different (13.1% for the MFS cohort and 13.0% for the AIS cohort (no difference by log-rank, p = 0.9).
conclusionWhile deformity surgery is much less commonly performed for MFS than AIS, it is not uncommonly considered for patients with this condition. Despite some known technical challenges for MFS deformity surgery, the current study leveraged a large, national database to find that 90-day adverse events and 5-year reoperations were not different for matched MFS and AIS patients undergoing deformity surgery. For select patients, these findings should be useful for surgical planning and patient counseling.
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