Evidence map›Paper›PMID 35362801›Full record

ReviewEuropean journal of applied physiology2022

Biomarkers and genetic polymorphisms associated with maximal fat oxidation during physical exercise: implications for metabolic health and sports performance.

Isaac A Chávez-Guevara, Rosa P Hernández-Torres, Everardo González-Rodríguez, Arnulfo Ramos-Jiménez, Francisco J Amaro-Gahete

Abstract readReview
PubMed Publisher
In one paragraph

Review in European journal of applied physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 2 pooled it
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 23 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Review
  5. Observational
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Review
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Isaac A Chávez-GuevaraDepartment of Chemical Sciences, Biomedical Sciences Institute, Ciudad Juarez Autonomous University, 32310, Chihuahua, Mexico.ORCID http://orcid.org/0000-0001-9773-5043
Rosa P Hernández-TorresFaculty of Physical Culture Sciences, Autonomous University of Chihuahua, 31000, Chihuahua, Mexico.
Everardo González-RodríguezFaculty of Medicine and Biomedical Sciences, Autonomous University of Chihuahua, Circuito Universitario, Campus II, 31109, Chihuahua, Mexico.ORCID http://orcid.org/0000-0003-0401-0073
Arnulfo Ramos-JiménezDepartment of Chemical Sciences, Biomedical Sciences Institute, Ciudad Juarez Autonomous University, 32310, Chihuahua, Mexico.ORCID http://orcid.org/0000-0002-4347-6725
Francisco J Amaro-GaheteEFFECTS-262 Research Group, Department of Medical Physiology, Faculty of Medicine, University of Granada, Granada, Spain. amarof@ugr.es.ORCID http://orcid.org/0000-0002-7207-9016
Autonomous University of Chihuahua · MXUniversidad Autónoma de Ciudad Juárez · MXUniversidad de Granada · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The maximal fat oxidation rate (MFO) assessed during a graded exercise test is a remarkable physiological indicator associated with metabolic flexibility, body weight loss and endurance performance. The present review considers existing biomarkers related to MFO, highlighting the validity of maximal oxygen uptake and free fatty acid availability for predicting MFO in athletes and healthy individuals. Moreover, we emphasize the role of different key enzymes and structural proteins that regulate adipose tissue lipolysis (i.e., triacylglycerol lipase, hormone sensitive lipase, perilipin 1), fatty acid trafficking (i.e., fatty acid translocase cluster of differentiation 36) and skeletal muscle oxidative capacity (i.e., citrate synthase and mitochondrial respiratory chain complexes II-V) on MFO variation. Likewise, we discuss the association of MFO with different polymorphism on the ACE, ADRB3, AR and CD36 genes, identifying prospective studies that will help to elucidate the mechanisms behind such associations. In addition, we highlight existing evidence that contradict the paradigm of a higher MFO in women due to ovarian hormones activity and highlight current gaps regarding endocrine function and MFO relationship.

Indexed as

Athletic PerformanceOxygen ConsumptionAdipose TissueBiomarkersExerciseFatty Acids, NonesterifiedFemaleHumansOxidation-ReductionPolymorphism, GeneticProspective StudiesReceptors, Adrenergic, beta-3ADRB3 protein, humanBiomarkersFatty Acids, NonesterifiedReceptors, Adrenergic, beta-3AthletesEnergy metabolismExerciseGene expressionGenotypeObesity

Identifiers

PMID35362801
OpenAlexW4220837357

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.