Evidence map›Paper›PMID 35362666›Full record

Trial reportBJOG : an international journal of obstetrics and gynaecology2022

Two-year follow-up of infant and maternal outcomes after planned early delivery or expectant management for late preterm pre-eclampsia (PHOENIX): A randomised controlled trial.

Alice Beardmore-Gray, Melanie Greenland, Louise Linsell, Edmund Juszczak, Pollyanna Hardy, Anna Placzek, Rachael Hunter, Jenie Sparkes, Marcus Green, Andrew Shennan and 3 more

Open access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BJOG : an international journal of obstetrics and gynaecology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 12 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 7 institutions in 1 country.

Alice Beardmore-GraySchool of Life Course Sciences, King's College London, London, UK.ORCID 0000-0001-9923-4912
Melanie GreenlandOxford Vaccine Group, University of Oxford, Oxford, UK.ORCID 0000-0001-9363-8844
Louise LinsellNational Perinatal Epidemiology Unit Clinical Trials Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.ORCID 0000-0003-3205-6511
Edmund JuszczakNational Perinatal Epidemiology Unit Clinical Trials Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.ORCID 0000-0001-5500-2247
Pollyanna HardyNational Perinatal Epidemiology Unit Clinical Trials Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.ORCID 0000-0003-2937-8368
Anna PlaczekExperimental Psychology Unit, University of Oxford, Oxford, UK.ORCID 0000-0002-6745-5996
Rachael HunterResearch Department of Primary Care and Population Health, University College London, London, UK.ORCID 0000-0002-7447-8934
Jenie SparkesSchool of Life Course Sciences, King's College London, London, UK.ORCID 0000-0002-9973-544X
Marcus GreenAction on Pre-eclampsia, Evesham, UK.ORCID 0000-0002-4561-8256
Andrew ShennanSchool of Life Course Sciences, King's College London, London, UK.ORCID 0000-0001-5273-3132
Neil MarlowInstitute for Women's Health, University College London, London, UK.ORCID 0000-0001-5890-2953
Lucy C ChappellSchool of Life Course Sciences, King's College London, London, UK.ORCID 0000-0001-6219-3379
PHOENIX Study Group
King's College London · GBUniversity of Oxford · GBAction for ME · GBLondon Women's Clinic · GBOxford Research Group · GBUniversity College London · GBUniversity of Nottingham · GB

Funding

Health Technology Assessment Programme 12/25/03
6 · The paper itself

Abstract

objectiveWe evaluated the best time to initiate delivery in late preterm pre-eclampsia in order to optimise long-term infant and maternal outcomes.

designParallel-group, non-masked, randomised controlled trial.

settingForty-six maternity units in the UK. POPULATION: Women with pre-eclampsia between 34

main outcome measuresInfant neurodevelopmental outcome at 2 years of age, using the Parent Report of Children's Abilities - Revised (PARCA-R) composite score.

resultsBetween 29 September 2014 and 10 December 2018, 901 women were enrolled in the trial, with 450 women allocated to planned delivery and 451 women allocated to expectant management. At the 2-year follow-up, the intention-to-treat analysis population included 276 women (290 infants) allocated to planned delivery and 251 women (256 infants) allocated to expectant management. The mean composite standardised PARCA-R scores were 89.5 (SD 18.2) in the planned delivery group and 91.9 (SD 18.4) in the expectant management group, with an adjusted mean difference of -2.4 points (95% CI -5.4 to 0.5 points).

conclusionsIn infants of women with late preterm pre-eclampsia, the average neurodevelopmental assessment at 2 years lies within the normal range, regardless of whether planned delivery or expectant management was pursued. With the lower than anticipated follow-up rate there was limited power to demonstrate that these scores did not differ, but the small between-group difference in PARCA-R scores is unlikely to be clinically important.

Indexed as

Pre-EclampsiaPremature BirthCesarean SectionChildDelivery, ObstetricFemaleFollow-Up StudiesHumansInfantInfant, NewbornPregnancyWatchful Waitingdeliveryinfantneurodevelopmentpre-eclampsiapreterm

Identifiers

PMID35362666
PMCPMC9545311
OpenAlexW4220852314

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.