ArticleThe European journal of neuroscience2022
A comparison of blood and brain-derived ageing and inflammation-related DNA methylation signatures and their association with microglial burdens.
Article in The European journal of neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 16 citations in OpenAlex.
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- Towards a personalized perspective on gliomas: an epigenetic-immuno-inflammatory aging framework.Frontiers in immunology · 2026Review
- Brain DNA Methylation Age, Lifestyle Factors and Dementia in the Swedish Twin Registry.Aging cell · 2025Article
- A blood- and brain-based EWAS of smoking.Nature communications · 2025Article
- Quantification of Epigenetic Aging in Public Health.Annual review of public health · 2025Review
- Examining epigenetic aging in the post-mortem brain in attention deficit hyperactivity disorder.Frontiers in genetics · 2024Article
- Advanced biological ageing predicts future risk for neurological diagnoses and clinical examination findings.Brain : a journal of neurology · 2023Article
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- Synaptic resilience is associated with maintained cognition during ageing.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2023Article
- Epigenetic clocks suggest accelerated aging in patients with isolated REM Sleep Behavior Disorder.NPJ Parkinson's disease · 2023Article
- Within subject cross-tissue analyzes of epigenetic clocks in substance use disorder postmortem brain and blood.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2023Article
- A comparison of blood and brain-derived ageing and inflammation-related DNA methylation signatures and their association with microglial burdens.The European journal of neuroscience · 2022Article
- DNA Methylation and Protein Markers of Chronic Inflammation and Their Associations With Brain and Cognitive Aging.Neurology · 2021Article
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22 authors at 7 institutions in 1 country.
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Abstract
Inflammation and ageing-related DNA methylation patterns in the blood have been linked to a variety of morbidities, including cognitive decline and neurodegenerative disease. However, it is unclear how these blood-based patterns relate to patterns within the brain and how each associates with central cellular profiles. In this study, we profiled DNA methylation in both the blood and in five post mortem brain regions (BA17, BA20/21, BA24, BA46 and hippocampus) in 14 individuals from the Lothian Birth Cohort 1936. Microglial burdens were additionally quantified in the same brain regions. DNA methylation signatures of five epigenetic ageing biomarkers ('epigenetic clocks'), and two inflammatory biomarkers (methylation proxies for C-reactive protein and interleukin-6) were compared across tissues and regions. Divergent associations between the inflammation and ageing signatures in the blood and brain were identified, depending on region assessed. Four out of the five assessed epigenetic age acceleration measures were found to be highest in the hippocampus (β range = 0.83-1.14, p ≤ 0.02). The inflammation-related DNA methylation signatures showed no clear variation across brain regions. Reactive microglial burdens were found to be highest in the hippocampus (β = 1.32, p = 5 × 10
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