ArticleJournal of the experimental analysis of behavior2022
Logical fallacies and misinterpretations that hinder progress in translational addiction neuroscience.
Article in Journal of the experimental analysis of behavior, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Opioid craving does not incubate over time in inpatient or outpatient treatment studies: Is the preclinical incubation of craving model lost in translation?Neuroscience and biobehavioral reviews · 2024Pooled it
- The Relative Reinforcing Value of Menthol Among Young Adult Cigarette Smokers: Results From a Behavioral Choice Task.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2025Article
- Overviewing the exponential model of demand and introducing a simplification that solves issues of span, scale, and zeros.Experimental and clinical psychopharmacology · 2025Review
- "I Can't Afford the Copays, So Guess I'll Die?" Using Discounting Methodology to Quantify How Cost Affects Health-Care Utilization.Behavior and social issues · 2024Article
- Enhancing translation: A need to leverage complex preclinical models of addictive drugs to accelerate substance use treatment options.Pharmacology, biochemistry, and behavior · 2024Review
- Impact of SMAASH-C, a novel nutritional supplement, on drug-seeking and toxicity in female and male rats.Translational psychiatry · 2024Article
- Next-day responsibilities attenuate demand for alcohol among a crowdsourced sample of community adults.Experimental and clinical psychopharmacology · 2023Article
- Socially Integrated Polysubstance (SIP) system: An open-source solution for continuous monitoring of polysubstance fluid intake in group housed mice.Addiction neuroscience · 2023Article
- The importance of translationally evaluating steroid hormone contributions to substance use.Frontiers in neuroendocrinology · 2023Review
- The antidepressant agomelatine attenuates morphine-induced reinstatement but not self-administration or precipitated withdrawal.Pharmacology, biochemistry, and behavior · 2023Article
- Hyperbolic discounting and exponentiated demand: Modeling demand for cigarettes in three dimensions.Journal of the experimental analysis of behavior · 2023Article
- Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Substance use disorders (SUDs) are heterogeneous and complex, making the development of translationally predictive rodent and nonhuman primate models to uncover their neurobehavioral underpinnings difficult. Neuroscience-focused outcomes have become highly prevalent, and with this, the notion that SUDs are disorders of the brain embraced as a dominant theoretical orientation to understand SUD etiology and treatment. These efforts, however, have led to few efficacious pharmacotherapies, and in some cases (as with cocaine or methamphetamine), no pharmacotherapies have translated from preclinical models for clinical use. In this theoretical commentary, we first describe the development of animal models of substance use behaviors from a historical perspective. We then define and discuss three logical fallacies including 1) circular explanation, 2) affirming the consequent, and 3) reification that can apply to developed models. We then provide three case examples in which conceptual or logical issues exist in common methods (i.e., behavioral economic demand, escalation, and reinstatement). Alternative strategies to refocus behavioral models are suggested for the field to better bridge the translational divide between animal models, the clinical condition of SUDs, and current and future regulatory pathways for intervention development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.