ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2022
Highly Stretchable Hydrogels as Wearable and Implantable Sensors for Recording Physiological and Brain Neural Signals.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 170 citations in OpenAlex.
- Recent Advances in Nanocomposite Hydrogel Sensors for Healthcare Applications: Fabrication Techniques, Multifunctionality and Challenges.Nanomaterials (Basel, Switzerland) · 2026Review
- Immuno-engineered conductive hydrogels: Bridging neural signaling and microenvironmental remodeling for neural repair.Materials today. Bio · 2026Article
- Hyaluronic Acid-Based Injectable Dual-Network Hydrogel for 6'-Sialyllactose Mimetic Peptide Delivery and Microenvironment Reconstruction in Brachial Plexus Root Avulsion.Advanced healthcare materials · 2026Article
- Systematic Benchmarking of a Noise-Tolerant Conductive Hydrogel Electrode for Epidermal Bioelectronics.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Epithelium-Inspired, Ultrahigh-Toughness, Ultralow-Hysteresis, and Highly Compressible Polymer Hydrogels as Self-Powered, Visual, and Underwater Strain Sensors.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Thermo-responsive, on-demand adhesive and tissue-conformal hydrogel electrodes for organ repair and brain-computer interfaces.Materials today. Bio · 2026Article
- Highly Sensitive MXene/MMT-Based Hydrogel for Wearable Sensors and Flexible Supercapacitors.Gels (Basel, Switzerland) · 2025Article
- Emerging Therapeutic Strategies in Intracerebral Hemorrhage: Enhancing Neurogenesis and Functional Recovery.MedComm · 2025Review
- Highly Stretchable, Self-Healable, and Conductive Gelatin Methacryloyl Hydrogel for Long-Lasting Wearable Tactile Sensors.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Flexible brain electronic sensors advance wearable brain-computer interface.npj biomedical innovations · 2025Review
- Bionic Sensors for Biometric Acquisition and Monitoring: Challenges and Opportunities.Sensors (Basel, Switzerland) · 2025Review
- Recent Progress of Soft and Bioactive Materials in Flexible Bioelectronics.Cyborg and bionic systems (Washington, D.C.) · 2025Review
- Magnetic Nanocomposite Hydrogels in Orthopedics: Applications and Perspectives.International journal of nanomedicine · 2025Review
- Physical stimuli-responsive polymeric patches for healthcare.Bioactive materials · 2025Review
- Implantable Passive Sensors for Biomedical Applications.Sensors (Basel, Switzerland) · 2024Review
- Silicon-Enhanced PVA Hydrogels in Flexible Sensors: Mechanism, Applications, and Recycling.Gels (Basel, Switzerland) · 2024Article
- One-Pot Synthesis of a Robust Crosslinker-Free Thermo-Reversible Conducting Hydrogel Electrode for Epidermal Electronics.ACS applied materials & interfaces · 2024Article
- Conducting polymer hydrogels based on supramolecular strategies for wearable sensors.Exploration (Beijing, China) · 2024Review
- Revolutionary Point-of-Care Wearable Diagnostics for Early Disease Detection and Biomarker Discovery through Intelligent Technologies.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Review
- Recent Advances of Stretchable Nanomaterial-Based Hydrogels for Wearable Sensors and Electrophysiological Signals Monitoring.Nanomaterials (Basel, Switzerland) · 2024Review
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
Recording electrophysiological information such as brain neural signals is of great importance in health monitoring and disease diagnosis. However, foreign body response and performance loss over time are major challenges stemming from the chemomechanical mismatch between sensors and tissues. Herein, microgels are utilized as large crosslinking centers in hydrogel networks to modulate the tradeoff between modulus and fatigue resistance/stretchability for producing hydrogels that closely match chemomechanical properties of neural tissues. The hydrogels exhibit notably different characteristics compared to nanoparticles reinforced hydrogels. The hydrogels exhibit relatively low modulus, good stretchability, and outstanding fatigue resistance. It is demonstrated that the hydrogels are well suited for fashioning into wearable and implantable sensors that can obtain physiological pressure signals, record the local field potentials in rat brains, and transmit signals through the injured peripheral nerves of rats. The hydrogels exhibit good chemomechanical match to tissues, negligible foreign body response, and minimal signal attenuation over an extended time, and as such is successfully demonstrated for use as long-term implantable sensory devices. This work facilitates a deeper understanding of biohybrid interfaces, while also advancing the technical design concepts for implantable neural probes that efficiently obtain physiological information.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.