SynthesisAlzheimer's & dementia : the journal of the Alzheimer's Association2023
The clinical profile of cerebral small vessel disease: Toward an evidence-based identification of cognitive markers.
Synthesis in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Risk prediction models for cognitive impairment in patients with cerebral small vessel disease: a systematic review and meta-analysis.Frontiers in aging neuroscience · 2026Pooled it
- The clinical profile of cerebral small vessel disease: Toward an evidence-based identification of cognitive markers.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2023Pooled it
- Early identification of vascular cognitive impairment from a multimodal perspective: a combined diagnosis from targeted cognitive assessments, imaging biomarkers, and molecular fluid biomarkers to ecological behavioral characteristics.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Review
- Neuro-Renal Crosstalk Across the Chronic Kidney Disease Spectrum: Stage-Dependent Molecular Mechanisms of Cognitive Impairment-An Integrative Review.International journal of molecular sciences · 2026Review
- Endothelial NOX4‑driven oxidative stress inhibition reverses HtrA1 deficiency‑induced blood‑brain barrier disruption and cognitive impairment.International journal of molecular medicine · 2026Article
- Associations between structural brain alterations and dysfunction across cognitive domains in cerebral small vessel disease: A systematic review and meta-analysis.Neuroimage. Reports · 2026Review
- Magnetic Resonance Imaging- Derived Cerebral Small Vessel Disease Burden and Association with Domain-Specific Cognition: A Cross-Sectional Study.Annals of Indian Academy of Neurology · 2026Article
- Editorial commentary: The usefulness of the new VasCog-2-WSO criteria for the diagnosis of vascular cognitive impairment and dementia.Cerebral circulation - cognition and behavior · 2026Article
- Research hotspots and trend of the heart-brain axis by MRI: a bibliometric analysis.Frontiers in cardiovascular medicine · 2026Article
- Recognizing, managing, and preventing cognitive sequelae after stroke. A narrative review.Cerebral circulation - cognition and behavior · 2026Review
- Article
- Neuropsychological Aspects of Sporadic Cerebral Amyloid Angiopathy: A Case Series and Narrative Review.Current Alzheimer research · 2025Review
- Executive functions and processing speed in covert cerebral small vessel disease.European journal of neurology · 2025Article
- Association between intercellular adhesion molecule-1 to depression and blood-brain barrier penetration in cerebellar vascular disease.World journal of psychiatry · 2024Article
- Pathogenesis of Cerebral Small Vessel Disease: Role of the Glymphatic System Dysfunction.International journal of molecular sciences · 2024Review
- Cognitive profile in cerebral small vessel disease: comparison between cerebral amyloid angiopathy and hypertension-related microangiopathy.Scientific reports · 2024Article
- Small vessel disease burden and functional brain connectivity in mild cognitive impairment.Cerebral circulation - cognition and behavior · 2024Article
- Regional cortical thinning, demyelination and iron loss in cerebral small vessel disease.Brain : a journal of neurology · 2023Article
- Blood-Brain Barrier Breakdown is a Sensitive Biomarker of Cognitive and Language Impairment in Patients with White Matter Hyperintensities.Neurology and therapy · 2023Article
- Relationship between Cognitive Impairment and Depressive Symptoms with Somatosensory Functions in Diabetic and Non-Diabetic Older Adults and Its Impact on Quality of Life.Life (Basel, Switzerland) · 2023Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There is no consensus on which test is more suited to outline the cognitive deficits of cerebral small vessel disease (cSVD) patients. We explored the ability of eight cognitive tests, selected in a previous systematic review as the most commonly used in this population, to differentiate among cSVD patients, controls, and other dementing conditions performing a meta-analysis of 86 studies. We found that cSVD patients performed worse than healthy controls in all tests while data on the comparison to neurodegenerative diseases were limited. We outlined a lack of data on these tests' accuracy on the diagnosis. Cognitive tests measuring processing speed were those mostly associated with neuroimaging cSVD markers. There is currently incomplete evidence that a single test could differentiate cSVD patients with cognitive decline from other dementing diseases. We make preliminary proposals on possible strategies to gain information about the clinical definition of cSVD that currently remains a neuroimaging-based one.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.