Evidence map›Paper›PMID 35362224›Full record

ArticleAdvanced healthcare materials2022

Enzyme-Mediated Alleviation of Peroxide Toxicity in Self-Oxygenating Biomaterials.

Niels G A Willemen, Shabir Hassan, Melvin Gurian, Maria Fernanda Jasso-Salazar, Kai Fan, Haihang Wang, Malin Becker, Iris E Allijn, Ayça Bal-Öztürk, Jeroen Leijten and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in Advanced healthcare materials, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
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  4. Article
  5. Review
  6. Autonomous Implants.Advanced materials (Deerfield Beach, Fla.) · 2025
    Review
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  8. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 5 countries.

Niels G A WillemenDivision of Engineering in Medicine, Department of Medicine, Harvard Medical School, and Brigham and Women's Hospital, Cambridge, MA, 02139, USA.ORCID 0000-0003-1061-3313
Shabir HassanDivision of Engineering in Medicine, Department of Medicine, Harvard Medical School, and Brigham and Women's Hospital, Cambridge, MA, 02139, USA.ORCID 0000-0002-5822-9508
Melvin GurianDepartment of Developmental BioEngineering, Faculty of Science and Technology, Technical Medical Centre, University of Twente, Drienerlolaan 5, Enschede, 7522 NB, The Netherlands.ORCID 0000-0001-5522-3875
Maria Fernanda Jasso-SalazarDivision of Engineering in Medicine, Department of Medicine, Harvard Medical School, and Brigham and Women's Hospital, Cambridge, MA, 02139, USA.ORCID 0000-0002-0209-2338
Kai FanDivision of Engineering in Medicine, Department of Medicine, Harvard Medical School, and Brigham and Women's Hospital, Cambridge, MA, 02139, USA.
Haihang WangDivision of Engineering in Medicine, Department of Medicine, Harvard Medical School, and Brigham and Women's Hospital, Cambridge, MA, 02139, USA.
Malin BeckerDepartment of Developmental BioEngineering, Faculty of Science and Technology, Technical Medical Centre, University of Twente, Drienerlolaan 5, Enschede, 7522 NB, The Netherlands.ORCID 0000-0002-5294-9715
Iris E AllijnDepartment of Developmental BioEngineering, Faculty of Science and Technology, Technical Medical Centre, University of Twente, Drienerlolaan 5, Enschede, 7522 NB, The Netherlands.ORCID 0000-0002-4026-3273
Ayça Bal-ÖztürkDepartment of Analytical Chemistry, Faculty of Pharmacy, Istinye University, Istanbul, 34010, Turkey.ORCID 0000-0002-6502-528X
Jeroen LeijtenDepartment of Developmental BioEngineering, Faculty of Science and Technology, Technical Medical Centre, University of Twente, Drienerlolaan 5, Enschede, 7522 NB, The Netherlands.
Su Ryon ShinDivision of Engineering in Medicine, Department of Medicine, Harvard Medical School, and Brigham and Women's Hospital, Cambridge, MA, 02139, USA.
Brigham and Women's Hospital · USUniversity of Twente · NLIstinye University · TR

Funding

Oxygen generating bioinks for 3D printed bone implantsR01AR074234 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI SHIN, SU RYON · 2018 to 2022
$1.9M
American Heart Association-American Stroke Association 19IPLOI34660079NIAMS NIH HHS R01 AR074234
6 · The paper itself

Abstract

Oxygen releasing biomaterials can facilitate the survival of living implants by creating environments with a viable oxygen level. Hydrophobic oxygen generating microparticles (HOGMPs) encapsulated calcium peroxide (CPO) have recently been used in tissue engineering to release physiologically relevant amounts of oxygen for several weeks. However, generating oxygen using CPO is mediated via the generation of toxic levels of hydrogen peroxide (H

Indexed as

Biocompatible MaterialsBioprintingCatalaseHydrogelsHydrogen PeroxideOxygenTissue EngineeringBiocompatible MaterialsCatalaseHydrogelsHydrogen PeroxideOxygen3D bioprintingcatalaseoxygen generationperoxide toxicitytissue engineering

Identifiers

PMID35362224
PMCPMC11041527
OpenAlexW4221058589

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.