ArticleBrain and behavior2022
The relationship between isolated hypertension with brain volumes in UK Biobank.
Article in Brain and behavior, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 14 citations in OpenAlex.
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- The impact of metabolic syndrome on the cerebral cortex: a Mendelian randomization study.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Discovery of High-Risk Clinical Factors That Accelerate Brain Aging in Adults: A Population-Based Machine Learning Study.Research (Washington, D.C.) · 2024Article
- Association between physical frailty and cortical structure in middle-aged and elderly people: a Mendelian randomization study.Frontiers in aging neuroscience · 2024Article
- White matter changes underlie hypertension-related cognitive decline in older adults.NeuroImage. Clinical · 2023Review
- The impact of early adversity on the cerebral cortex - a Mendelian randomization study.Frontiers in neuroscience · 2023Article
- Understanding the inter-relationships of type 2 diabetes and hypertension with brain and cognitive health: A UK Biobank study.Diabetes, obesity & metabolism · 2022Article
- The relationship between isolated hypertension with brain volumes in UK Biobank.Brain and behavior · 2022Article
- Associations between abdominal adipose tissue, reproductive span, and brain characteristics in post-menopausal women.NeuroImage. Clinical · 2022Article
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundHypertension is a well-established risk factor for cognitive impairment, brain atrophy, and dementia. However, the relationship of other types of hypertensions, such as isolated hypertension on brain health and its comparison to systolic-diastolic hypertension (where systolic and diastolic measures are high), is still relatively unknown. Due to its increased prevalence, it is important to investigate the impact of isolated hypertension to help understand its potential impact on cognitive decline and future dementia risk. In this study, we compared a variety of global brain measures between participants with isolated hypertension to those with normal blood pressure (BP) or systolic-diastolic hypertension using the largest cohort of healthy individuals.
methodsUsing the UK Biobank cohort, we carried out a cross-sectional study using 29,775 participants (mean age 63 years, 53% female) with BP measurements and brain magnetic resonance imaging (MRI) data. We used linear regression models adjusted for multiple confounders to compare a variety of global, subcortical, and white matter brain measures. We compared participants with either isolated systolic or diastolic hypertension with normotensives and then with participants with systolic-diastolic hypertension.
resultsThe results showed that participants with isolated systolic or diastolic hypertension taking BP medications had smaller gray matter but larger white matter microstructures and macrostructures compared to normotensives. Isolated systolic hypertensives had larger total gray matter and smaller white matter traits when comparing these regions with participants with systolic-diastolic hypertension.
conclusionsThese results provide support to investigate possible preventative strategies that target isolated hypertension as well as systolic-diastolic hypertension to maintain brain health and/or reduce dementia risk earlier in life particularly in white matter regions.
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