ArticleAmerican journal of epidemiology2022
Cardiometabolic Pregnancy Complications in Association With Autism-Related Traits as Measured by the Social Responsiveness Scale in ECHO.
Article in American journal of epidemiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03061890 (Developmental Impact of Neonatal Intensive Care Unit), which is not on this map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Developmental Impact of Neonatal Intensive Care Unit (NICU) Exposures: Environmental Influences on Child Health Outcomes (ECHO)
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- Hypertensive disorders of pregnancy and childhood neurodevelopment: A systematic review and meta-analysis.PLoS medicine · 2025Pooled it
- Prenatal targeted maternal pregnancy metabolomic profiles, child emotional and behavioral problems, and autism related traits in the NYU CHES cohort.Molecular psychiatry · 2026Article
- Developmental Trajectories of Autistic Social Traits in Youth Born Extremely Preterm.Journal of the American Academy of Child and Adolescent Psychiatry · 2026Article
- Prenatal Air Pollution Exposure and Autism Spectrum Disorder in the ECHO Consortium.Environmental health perspectives · 2026Article
- Prenatal Glucose Intolerance and Child Neurodevelopmental Disorders.JAMA network open · 2025Article
- Demographic Correlates of Autism: How Do Associations Compare Between Diagnosis and a Quantitative Trait Measure?Autism research : official journal of the International Society for Autism Research · 2025Article
- Characterizing self-reported physical activity before and during a subsequent pregnancy among parents in a familial autism cohort.Autism : the international journal of research and practice · 2025Article
- An Examination of Family Transmission of Traits Measured by the Social Responsiveness Scale-Short Form.Journal of autism and developmental disorders · 2024Article
- Regional differences in autism and intellectual disability risk associated with cesarean section delivery.Autism research : official journal of the International Society for Autism Research · 2024Article
- Impact of interaction between individual genomes and preeclampsia on the severity of autism spectrum disorder symptoms.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2024Article
- Prenatal air pollution and children's autism traits score: Examination of joint associations with maternal intake of vitamin D, methyl donors, and polyunsaturated fatty acids using mixture methods.Environmental epidemiology (Philadelphia, Pa.) · 2024Article
- Maternal obesity and diabetes during pregnancy and early autism screening score at well-child visits in standard clinical practice.Autism : the international journal of research and practice · 2024Article
- Severity of Autism Spectrum Disorder Symptoms Associated with de novo Variants and Pregnancy-Induced Hypertension.Journal of autism and developmental disorders · 2024Article
- Sex-specific and sex-independent steroid-related biomarkers in early second trimester maternal serum associated with autism.Molecular autism · 2023Article
- The Environmental Influences on Child Health Outcomes (ECHO)-Wide Cohort.American journal of epidemiology · 2023Article
- What are quantitative traits and how can they be used in autism research?Autism research : official journal of the International Society for Autism Research · 2023Article
- Article
Corrections and comments
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Authors and funding
41 authors.
Funding
Abstract
Prior work has examined associations between cardiometabolic pregnancy complications and autism spectrum disorder (ASD) but not how these complications may relate to social communication traits more broadly. We addressed this question within the Environmental Influences on Child Health Outcomes program, with 6,778 participants from 40 cohorts conducted from 1998-2021 with information on ASD-related traits via the Social Responsiveness Scale. Four metabolic pregnancy complications were examined individually, and combined, in association with Social Responsiveness Scale scores, using crude and adjusted linear regression as well as quantile regression analyses. We also examined associations stratified by ASD diagnosis, and potential mediation by preterm birth and low birth weight, and modification by child sex and enriched risk of ASD. Increases in ASD-related traits were associated with obesity (β = 4.64, 95% confidence interval: 3.27, 6.01) and gestational diabetes (β = 5.21, 95% confidence interval: 2.41, 8.02), specifically, but not with hypertension or preeclampsia. Results among children without ASD were similar to main analyses, but weaker among ASD cases. There was not strong evidence for mediation or modification. Results suggest that common cardiometabolic pregnancy complications may influence child ASD-related traits, not only above a diagnostic threshold relevant to ASD but also across the population.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.