Evidence map›Paper›PMID 35361906›Full record

ReviewMucosal immunology2022

Skin immunity: dissecting the complex biology of our body's outer barrier.

Chenlu Zhang, Geil R Merana, Tamia Harris-Tryon, Tiffany C Scharschmidt

Abstract readReview
PubMed Publisher
In one paragraph

Review in Mucosal immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed.

  1. Review
  2. Review
  3. Phytochemical Profiling and Computational Screening ofPharmaceuticals (Basel, Switzerland) · 2026
    Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Review
  10. The systemic costs of hematopoietic stem cell aging.Development (Cambridge, England) · 2025
    Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Review
  19. Microbes Saving Lives and Reducing Suffering.Microbial biotechnology · 2025
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Chenlu ZhangUniversity of Texas Southwestern, Department of Dermatology, Dallas, TX, USA.
Geil R MeranaUniversity of California, San Francisco, Department of Dermatology, San Francisco, CA, USA.
Tamia Harris-TryonUniversity of Texas Southwestern, Department of Dermatology, Dallas, TX, USA. Tamia.Harris-Tryon@UTSouthwestern.edu.
Tiffany C ScharschmidtUniversity of California, San Francisco, Department of Dermatology, San Francisco, CA, USA. Tiffany.Scharschmidt@ucsf.edu.

Funding

Decoding and harnessing microbial tuning of T cell responses in early lifeDP2AI144968 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SCHARSCHMIDT, TIFFANY CRAWFORD · 2018 to 2018
$2.4M
The Function of Small Proline Rich Proteins in Cutaneous Host DefenseK08AR076459 · NIAMS · UT SOUTHWESTERN MEDICAL CENTER · PI HARRIS-TRYON, TAMIA ALISHA · 2020 to 2024
$798k
NIAID NIH HHS DP2 AI144968NIAMS NIH HHS K08 AR076459
6 · The paper itself

Abstract

Our skin contributes critically to health via its role as a barrier tissue, carefully regulating passage of key substrates while also providing defense against exogenous threats. Immunological processes are integral to almost every skin function and paramount to our ability to live symbiotically with skin commensal microbes and other environmental stimuli. While many parallels can be drawn to immunobiology at other mucosal sites, skin immunity demonstrates unique features that relate to its distinct topography, chemical composition and microbial ecology. Here we provide an overview of skin as an immune organ, with reference to the broader context of mucosal immunology. We review paradigms of innate as well as adaptive immune function and highlight how skin-specific structures such as hair follicles and sebaceous glands interact and contribute to these processes. Finally, we highlight for the mucosal immunology community a few emerging areas of interest for the skin immunity field moving forward.

Indexed as

Mucous MembraneSymbiosisBiologyImmunity, Innate

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.