Evidence map›Paper›PMID 35361857›Full record

ArticleScientific reports2022

Stent-based delivery of AAV2 vectors encoding oxidation-resistant apoA1.

Bahman Hooshdaran, Benjamin B Pressly, Ivan S Alferiev, Jonathan D Smith, Philip W Zoltick, Cory M Tschabrunn, Robert L Wilensky, Robert C Gorman, Robert J Levy, Ilia Fishbein

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Carbamylated lipoproteins in diabetes.World journal of diabetes · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Bahman Hooshdaran *Division of Cardiology, The Children's Hospital of Philadelphia, 3615 Civic Center Blvd, CHOP, ARC, Room 702 C, Philadelphia, PA, 19104, USA.
Benjamin B Pressly *Division of Cardiology, The Children's Hospital of Philadelphia, 3615 Civic Center Blvd, CHOP, ARC, Room 702 C, Philadelphia, PA, 19104, USA.
Ivan S AlferievDivision of Cardiology, The Children's Hospital of Philadelphia, 3615 Civic Center Blvd, CHOP, ARC, Room 702 C, Philadelphia, PA, 19104, USA.
Jonathan D SmithDepartment of Cardiovascular and Metabolic Sciences, Cleveland Clinic, Cleveland, USA.
Philip W ZoltickDivision of Cardiology, The Children's Hospital of Philadelphia, 3615 Civic Center Blvd, CHOP, ARC, Room 702 C, Philadelphia, PA, 19104, USA.
Cory M TschabrunnDepartment of Medicine, Division of Cardiovascular Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, USA.
Robert L WilenskyDepartment of Medicine, Division of Cardiovascular Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, USA.
Robert C GormanDepartment of Surgery, University of Pennsylvania Perelman School of Medicine, Philadelphia, USA.
Robert J LevyDivision of Cardiology, The Children's Hospital of Philadelphia, 3615 Civic Center Blvd, CHOP, ARC, Room 702 C, Philadelphia, PA, 19104, USA.
Ilia FishbeinDivision of Cardiology, The Children's Hospital of Philadelphia, 3615 Civic Center Blvd, CHOP, ARC, Room 702 C, Philadelphia, PA, 19104, USA. fishbein@chop.edu.
University of Pennsylvania · USChildren's Hospital of Philadelphia · USCleveland Clinic · US

Funding

Oxidation Resistant ApoA1 Gene Delivery StentsR01HL137762 · NHLBI · CHILDREN'S HOSP OF PHILADELPHIA · PI FISHBEIN, ILIA, LEVY, ROBERT J · 2017 to 2020
$3.3M
Oxidant resistant apoA1 in reverse cholesterol transport, inflammation and atherosclerosisR01HL130085 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI SMITH, JONATHAN D · 2016 to 2019
$1.6M
NHLBI NIH HHS R01 HL130085NHLBI NIH HHS R01 HL137762NIH HHS HL130085NIH HHS HL137762
6 · The paper itself

Abstract

In-stent restenosis (ISR) complicates revascularization in the coronary and peripheral arteries. Apolipoprotein A1 (apoA1), the principal protein component of HDL possesses inherent anti-atherosclerotic and anti-restenotic properties. These beneficial traits are lost when wild type apoA1(WT) is subjected to oxidative modifications. We investigated whether local delivery of adeno-associated viral (AAV) vectors expressing oxidation-resistant apoA1(4WF) preserves apoA1 functionality. The efflux of

Indexed as

Apolipoprotein A-IDependovirusAnimalsEndothelial CellsGenetic VectorsRatsStentsSwineApolipoprotein A-I

Identifiers

PMID35361857
PMCPMC8971450
OpenAlexW4221052766

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.