ArticleTranslational psychiatry2022
Developing symptom clusters: linking inflammatory biomarkers to depressive symptom profiles.
Article in Translational psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 34 citations in OpenAlex.
- Ensemble clustering: A practical tutorial.Behavior research methods · 2026Article
- The synaptic triad in depression: how stress-related pathways converge on BDNF, NMDA receptor, and MMP-9.Pharmacological reports : PR · 2026Review
- The kynurenine pathway in depression and schizophrenia: convergent signals, divergent states, and clinical signatures.EXCLI journal · 2026Review
- External factors show reproducible local symptom-biomarker associations in middle-aged and older adults with heart disease.Frontiers in psychiatry · 2026Article
- Associations Between Irrational Beliefs and Inflammatory Biomarkers: A Brief Research Report.International journal of behavioral medicine · 2025Article
- Inflammatory profiles of transdiagnostic symptom dimensions in healthy females.Brain, behavior, & immunity - health · 2025Article
- Associations of uric acid and lipids with depression, dimensions of depression and anxiety symptoms.Discover mental health · 2025Article
- Chronic Stress Disrupts Immune and Endocrine Axis, Inducing Persistent Behavioral Impairments in Male Rats: In Silico and In Vivo Insights.Neurochemical research · 2025Article
- Inflammatory and MRI perfusion biomarkers in predicting persistence of depression: a 6-month Longitudinal Study.Translational psychiatry · 2025Article
- The inflammation-depression link: How social networks buffer or exacerbate risk.Brain, behavior, & immunity - health · 2025Article
- From Biomarkers to Behavior: Mapping the Neuroimmune Web of Pain, Mood, and Memory.Biomedicines · 2025Article
- A Systematic Review: Investigating Biomarkers of Anhedonia and Amotivation in Depression and Cannabis Use.JAACAP open · 2025Review
- Clustering and drivers of symptoms observed at week six after antidepressant treatment in depressed outpatients.European psychiatry : the journal of the Association of European Psychiatrists · 2025Article
- Associations between biomarkers of inflammation and depressive symptoms-potential differences between diabetes types and symptom clusters of depression.Translational psychiatry · 2025Article
- Association between neutrophil-to-lymphocyte ratio and specific depressive symptoms: an analysis of a population-based cross-sectional survey.BMC psychiatry · 2024Article
- The links between neuroinflammation, brain structure and depressive disorder: A cross-sectional study protocol.PloS one · 2024Observational
- Associations Between Neuropsychiatric Symptoms and Inflammation in Neurodegenerative Dementia: A Systematic Review.Journal of inflammation research · 2024Review
- Neuroinflammation in the Amygdala Is Associated With Recent Depressive Symptoms.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2023Article
- Examining Risk Factors in the Cannabis-Suicide Link: Considering Trauma and Impulsivity among University Students.International journal of environmental research and public health · 2022Article
- Depressive symptoms predict longitudinal changes of chronic inflammation at the transition to adulthood.Frontiers in immunology · 2022Article
Corrections and comments
- Erratum issued
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Considering the burden of depression and the lack of efficacy of available treatments, there is a need for biomarkers to predict tailored or personalized treatments. However, identifying reliable biomarkers for depression has been challenging, likely owing to the vast symptom heterogeneity and high rates of comorbidity that exists. Examining biomarkers that map onto dimensions of depression as well as shared symptoms/constructs that cut across disorders could be most effective for informing personalized treatment approaches. With a sample of 539 young adults, we conducted a principal component analysis (PCA) followed by hierarchical cluster analysis to develop transdiagnostic clusters of depression and anxiety symptoms. We collected blood to assess whether neuroendocrine (cortisol) and inflammatory profiles (C-reactive protein (CRP), Interleukin (IL)-6, and tumor necrosis factor (TNF) - α) could be used to differentiate symptom clusters. Six distinct clusters were identified that differed significantly on symptom dimensions including somatic anxiety, general anxiety, anhedonia, and neurovegetative depression. Moreover, the neurovegetative depression cluster displayed significantly elevated CRP levels compared to other clusters. In fact, inflammation was not strongly associated with overall depression scores or severity, but rather related to specific features of depression marked by eating, appetite, and tiredness. This study emphasizes the importance of characterizing the biological underpinnings of symptom dimensions and subtypes to better understand the etiology of complex mental health disorders such as depression.
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