ArticleNPJ microgravity2022
Estimating medical risk in human spaceflight.
Article in NPJ microgravity, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed.
- Cardiovascular risks and hazards associated with deep space exploration.Communications medicine · 2026Review
- Communication delay increases procedure time and instructor task load during simulated suturing by novices.NPJ microgravity · 2026Article
- Biomedicine and Biotechnology in Space: An Introduction.Methods in molecular biology (Clifton, N.J.) · 2026Article
- Effect of microgravity on the feasibility and accuracy of dental procedures.NPJ microgravity · 2025Article
- Spaceflight Standard Measures is a multidisciplinary study that systematically monitors risks to astronaut health and performance.NPJ microgravity · 2025Review
- Spaceflight exposome/microgravity effects on the psychoimmunoneuroendocrine system.NPJ microgravity · 2025Review
- Space flight missions over 6 months significantly increase the risk of shoulder pathology and rotator cuff tears.JSES international · 2025Article
- Repetitive stability study of remdesivir/cyclodextrin complex on the international space station.Scientific reports · 2025Article
- Articular cartilage loss is an unmitigated risk of human spaceflight.NPJ microgravity · 2024Review
- Nitrosative Stress in Astronaut Skeletal Muscle in Spaceflight.Antioxidants (Basel, Switzerland) · 2024Article
- Levels of evidence for human system risk evaluation.NPJ microgravity · 2024Review
- The human biology of spaceflight.American journal of human biology : the official journal of the Human Biology Council · 2024Article
- Updates to the NASA human system risk management process for space exploration.NPJ microgravity · 2023Review
- The value of a spaceflight clinical decision support system for earth-independent medical operations.NPJ microgravity · 2023Review
- Ocular conditions and injuries, detection and management in spaceflight.NPJ microgravity · 2023Review
- Space Omics and Tissue Response in Astronaut Skeletal Muscle after Short and Long Duration Missions.International journal of molecular sciences · 2023Article
- Reinforcement learned adversarial agent (ReLAA) for active fault detection and prediction in space habitats.NPJ microgravity · 2023Article
- Evaluation of deep space exploration risks and mitigations against radiation and microgravity.Frontiers in nuclear medicine · 2023Review
- Enabling Human Space Exploration Missions Through Progressively Earth Independent Medical Operations (EIMO).IEEE open journal of engineering in medicine and biology · 2023Article
- Time-resolved molecular measurements reveal changes in astronauts during spaceflight.Frontiers in physiology · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
NASA and commercial spaceflight companies will soon be retuning humans to the Moon and then eventually sending them on to Mars. These distant planetary destinations will pose new risks-in particular for the health of the astronaut crews. The bulk of the evidence characterizing human health and performance in spaceflight has come from missions in Low Earth Orbit. As missions last longer and travel farther from Earth, medical risk is expected to contribute an increasing proportion of total mission risk. To date, there have been no reliable estimates of how much. The Integrated Medical Model (IMM) is a Probabilistic Risk Assessment (PRA) Monte-Carlo simulation tool developed by NASA for medical risk assessment. This paper uses the IMM to provide an evidence-based, quantified medical risk estimate comparison across different spaceflight mission durations. We discuss model limitations and unimplemented capabilities providing insight into the complexity of medical risk estimation for human spaceflight. The results enable prioritization of medical needs in the context of other mission risks. These findings provide a reasonable bounding estimate for medical risk in missions to the Moon and Mars and hold value for risk managers and mission planners in performing cost-benefit trades for mission capability and research investments.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.