Evidence map›Paper›PMID 35361699›Full record

SynthesisJournal of psychiatry & neuroscience : JPN

Impairing memory reconsolidation with propranolol in healthy and clinical samples: a meta-analysis.

Sereena Pigeon, Michelle Lonergan, Olivia Rotondo, Roger K Pitman, Alain Brunet

Open access · diamondAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of psychiatry & neuroscience : JPN. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
5.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 51 citations in OpenAlex.

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  18. Memory Sins in Applied Settings: What Kind of Progress?Journal of applied research in memory and cognition · 2022
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 3 countries.

Sereena PigeonFrom McGill University, Montréal, Que., Canada (Pigeon, Lonergan, Rotondo, Brunet); the Douglas Mental Health University Institute Research Center, Montréal, Que., Canada (Pigeon, Lonergan, Rotondo, Brunet); the School of Psychology, University of Ottawa, Ottawa, Ont., Canada (Lonergan); and the Department of Psychiatry, Harvard Medical School, Charlestown, Mass., USA (Pitman).
Michelle LonerganFrom McGill University, Montréal, Que., Canada (Pigeon, Lonergan, Rotondo, Brunet); the Douglas Mental Health University Institute Research Center, Montréal, Que., Canada (Pigeon, Lonergan, Rotondo, Brunet); the School of Psychology, University of Ottawa, Ottawa, Ont., Canada (Lonergan); and the Department of Psychiatry, Harvard Medical School, Charlestown, Mass., USA (Pitman).
Olivia RotondoFrom McGill University, Montréal, Que., Canada (Pigeon, Lonergan, Rotondo, Brunet); the Douglas Mental Health University Institute Research Center, Montréal, Que., Canada (Pigeon, Lonergan, Rotondo, Brunet); the School of Psychology, University of Ottawa, Ottawa, Ont., Canada (Lonergan); and the Department of Psychiatry, Harvard Medical School, Charlestown, Mass., USA (Pitman).
Roger K PitmanFrom McGill University, Montréal, Que., Canada (Pigeon, Lonergan, Rotondo, Brunet); the Douglas Mental Health University Institute Research Center, Montréal, Que., Canada (Pigeon, Lonergan, Rotondo, Brunet); the School of Psychology, University of Ottawa, Ottawa, Ont., Canada (Lonergan); and the Department of Psychiatry, Harvard Medical School, Charlestown, Mass., USA (Pitman).
Alain BrunetFrom McGill University, Montréal, Que., Canada (Pigeon, Lonergan, Rotondo, Brunet); the Douglas Mental Health University Institute Research Center, Montréal, Que., Canada (Pigeon, Lonergan, Rotondo, Brunet); the School of Psychology, University of Ottawa, Ottawa, Ont., Canada (Lonergan); and the Department of Psychiatry, Harvard Medical School, Charlestown, Mass., USA (Pitman) alain.brunet@mcgill.ca.
Douglas Mental Health University Institute · CAHarvard University · USUniversity of Ottawa · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundReconsolidation impairment using propranolol is a novel intervention for mental disorders with an emotional memory at their core. In this systematic review and meta-analysis, we examined the evidence for this intervention in healthy and clinical adult samples.

methodsWe searched 8 databases for randomized, double-blind studies that involved at least 1 propranolol group and 1 placebo group. We conducted a meta-analysis of 14 studies (

resultsCompared to placebo, reconsolidation impairment under propranolol resulted in reduced recall of aversive material and cue-elicited conditioned emotional responses in healthy adults, as evidenced by an effect size (Hedges LIMITATIONS: Methodological differences between studies posed an obstacle for identifying sources of heterogeneity.

conclusionReconsolidation impairment is a robust, well-replicated phenomenon in humans. Its clinical use is promising and deserves further controlled investigation.

Indexed as

Adrenergic beta-AntagonistsPropranololAdultEmotionsHumansMental RecallRandomized Controlled Trials as TopicAdrenergic beta-AntagonistsPropranolol

Identifiers

PMID35361699
PMCPMC8979654
OpenAlexW4220859059

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.