Evidence map›Paper›PMID 35361556›Full record

Trial reportNeuroImage. Clinical2022

Hippocampal maintenance after a 12-month physical activity intervention in older adults: The REACT MRI study.

Naiara Demnitz, Afroditi Stathi, Janet Withall, Candida Stainer, Poppy Seager, Jolanthe De Koning, Patrick Esser, Thomas Wassenaar, Helen Dawes, Jonathan Brooks and 3 more

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in NeuroImage. Clinical, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact, top 88% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 1 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Muscle fibre denervation in ageing.Clinical science (London, England : 1979) · 2026
    Review
  5. Article
  6. Article
  7. Review
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 1 country.

Naiara DemnitzDepartment of Psychiatry, University of Oxford, Warneford Hospital, Oxford OX3 7JX, UK; Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital - Amager and Hvidovre, 2650 Hvidovre, Denmark. Electronic address: naiara.demnitz@gbhi.org.
Afroditi StathiSchool of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, Birmingham B15 2TT, UK.
Janet WithallDepartment for Health, University of Bath, Bath BA2 7AY, UK.
Candida StainerWellcome Centre for Integrative Neuroimaging, FMRIB Centre, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK.
Poppy SeagerWellcome Centre for Integrative Neuroimaging, FMRIB Centre, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK.
Jolanthe De KoningDepartment for Health, University of Bath, Bath BA2 7AY, UK.
Patrick EsserCentre for Movement, Occupation and Rehabilitation Sciences, Faculty of Health and Life Sciences, Oxford Brookes University, Oxford OX3 0FL, UK.
Thomas WassenaarWellcome Centre for Integrative Neuroimaging, FMRIB Centre, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK.
Helen DawesCentre for Movement, Occupation and Rehabilitation Sciences, Faculty of Health and Life Sciences, Oxford Brookes University, Oxford OX3 0FL, UK.
Jonathan BrooksClinical Research and Imaging Centre, University of Bristol, Bristol BS2 8DX, UK.
Klaus P EbmeierDepartment of Psychiatry, University of Oxford, Warneford Hospital, Oxford OX3 7JX, UK.
Heidi Johansen-BergWellcome Centre for Integrative Neuroimaging, FMRIB Centre, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK.
Claire E SextonWellcome Centre for Integrative Neuroimaging, FMRIB Centre, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK.
University of Oxford · GBWellcome Centre for Integrative Neuroimaging · GBOxford Brookes University · GBUniversity of Bath · GBUniversity of Birmingham · GBUniversity of Bristol · GB

Funding

Department of Health 13/164/ 51Medical Research Council G1001354Wellcome Trust 110027/Z/15/ZWellcome Trust 203139/Z/16/Z
6 · The paper itself

Abstract

backgroundPhysical activity interventions have had varying results on modifying hippocampal volume.

methodsThe Retirement in Action (REACT) study conducted a randomised-controlled trial of a 12-month physical activity and behaviour maintenance intervention in older adults at risk of mobility impairments. The physical activity sessions were delivered twice weekly for the first twelve weeks, and then reduced to once weekly, to groups of 15 participants. Activities included cardiovascular, strength, balance and flexibility exercises. A sub-sample of participants in the physical activity (N = 54) and control arms (N = 48) underwent a 3 T MRI brain scan and cognitive assessments at baseline, 6- and 12-months (mean age = 76.6 years, 6.8 SD). It was hypothesised that the intervention would lead to a reduced rate of decline in hippocampal volume. Group differences in changes in cognition were also examined.

resultsAs hypothesised, we found a maintenance in left hippocampal volume in the intervention arm, in comparison with the control arm after 12 months (p = 0.027). In a secondary analysis, this effect was attenuated after including age, sex and education level as covariates (p = 0.057). There was no significant between-group difference in the right hippocampus (p = 0.405). Contrary to our hypothesis, we did not find a beneficial effect of the intervention on cognitive outcomes.

conclusionsOur findings suggest that a community-based physical activity intervention can significantly ward-off hippocampal atrophy in older adults. While the lack of effects on cognition may limit the interpretability of our results, our findings of hippocampal maintenance are promising given the potential clinical relevance of protecting the hippocampus from age-related decline.

Indexed as

ExerciseExercise TherapyAgedBehavior TherapyHippocampusHumansMagnetic Resonance ImagingAgeingExerciseHippocampusMobilityRCT

Identifiers

PMID35361556
PMCPMC9421470
OpenAlexW3179495788

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.