Evidence map›Paper›PMID 35361540›Full record

ArticleSurgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery2022

Measures of glucose homeostasis during and after duodenal exclusion using a duodenal-jejunal bypass liner in a normoglycemic, nonobese canine model.

Rebecca L Paszkiewicz, Miguel A Burch, Isaac Asare Bediako, Hasmik Mkrtchyan, Francesca Piccinini, Marilyn Ader, Catherine Bresee, Richard N Bergman

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Article in Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Rebecca L PaszkiewiczDiabetes and Obesity Research Institute, Cedars-Sinai Medical Center, Los Angeles, California. Electronic address: rpaszkiewicz@mednet.ucla.edu.
Miguel A BurchMinimally Invasive and GI Surgery, Cedars-Sinai Medical Center, Los Angeles, California.
Isaac Asare BediakoDiabetes and Obesity Research Institute, Cedars-Sinai Medical Center, Los Angeles, California.
Hasmik MkrtchyanDiabetes and Obesity Research Institute, Cedars-Sinai Medical Center, Los Angeles, California.
Francesca PiccininiDiabetes and Obesity Research Institute, Cedars-Sinai Medical Center, Los Angeles, California.
Marilyn AderDiabetes and Obesity Research Institute, Cedars-Sinai Medical Center, Los Angeles, California.
Catherine BreseeSamuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California.
Richard N BergmanDiabetes and Obesity Research Institute, Cedars-Sinai Medical Center, Los Angeles, California.

Funding

QUANTITATION OF FACTORS REGULATING GLUCOSE TOLERANCER01DK029867 · NIDDK · UNIVERSITY OF SOUTHERN CALIFORNIA · PI MARILYN ADER · 1986 to 2026
$11.0M
QUANTITATIVE STUDIES OF METABOLIC ORGAN DYNAMICSR01DK027619 · NIDDK · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BERGMAN, RICHARD NATHAN · 1986 to 2022
$6.2M
NIDDK NIH HHS R01 DK027619NIDDK NIH HHS R01 DK029867
6 · The paper itself

Abstract

backgroundDiscovering the role duodenal exclusion plays in weight loss and resolution of type 2 diabetes (T2D) may help refine the surgical and nonsurgical treatment of obesity and T2D.

objectivesTo assess changes in glucose homeostasis due to duodenal exclusion using a duodenal-jejunal bypass liner (DJBL) in a nonobese canine model.

settingAcademic laboratory setting.

methodsAn intravenous glucose tolerance test (IVGTT), and a mixed-meal tolerance test (MMTT) at baseline, 1, and 6 weeks post DJBL implantation (I1 and I6, respectively), and 1 and 6 weeks post DJBL removal (R1 and R6, respectively) were done in canines (n = 7) fed a normal chow diet.

resultsPlacement of the DJBL induced weight loss that was maintained until 4 weeks post removal (R4), despite normal food intake. Total bile acids (TBA) and glucagon-like peptide-1 (GLP-1) during the MMTT were significantly increased at I1 and were associated with increased lactate and free fatty acids. Hypoglycemia counter-regulation was blunted during the IVGTT at I1 and I6, returning to baseline at R1. While there were no changes to insulin sensitivity during the experiment, glucose tolerance was significantly increased following the removal of the DJBL at R1.

conclusionThese data show that in a normoglycemic, nonobese canine model, duodenal exclusion induces energy intake-independent weight loss and negative metabolic effects that are reversed following re-exposure of the small intestine to nutrients.

Indexed as

Bariatric SurgeryDiabetes Mellitus, Type 2AnimalsBlood GlucoseDogsDuodenumGlucoseHomeostasisHumansJejunumTreatment OutcomeWeight LossBlood GlucoseGlucoseBariatric surgeryDuodenal exclusionDuodenal-jejunal bypass linerObesityType 2 diabetes

Identifiers

PMID35361540
PMCPMC10013877

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.