Evidence map›Paper›PMID 35361275›Full record

ArticleJournal of pharmaceutical health care and sciences2022

Transfer of brotizolam, periciazine, and sulpiride in cord blood and breast milk, and alprazolam in breast milk: a case report.

Jumpei Saito, Yoshiyuki Tachibana, Yuka Sano Wada, Naho Yakuwa, Hiroyo Kawasaki, Tomo Suzuki, Haruhiko Sago, Akimasa Yamatani, Atsuko Murashima

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of pharmaceutical health care and sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06001021 (The Effectiveness of Psychopharmacological Intervention Versus Cognitive Behavioral Couple Therapy and Their Combination in Perinatal Distressed Couples), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06001021 nacompletednot on this mapstarted 2023, after this paper: background citation

The Effectiveness of Psychopharmacological Intervention Versus Cognitive Behavioral Couple Therapy and Their Combination in Perinatal Distressed Couples: A Randomized Clinical Trial

TypeinterventionalSponsorSameera ShafiqRan2023 to 2023Enrolled96ConditionsPerinatal Depression, Perinatal AnxietyArmsPsychopharmacological Intervention, Cognitive Behavioral Couple Therapy, Combination of Psychopharmacological Intervention and CBCT, Placebo and No Intervention
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Jumpei SaitoDepartment of Pharmacy, National Center for Child Health and Development, Tokyo, Japan. saito-jn@ncchd.go.jp.ORCID http://orcid.org/0000-0003-4799-5562
Yoshiyuki TachibanaDivision of Infant and Toddler Mental Health, Department of Psychosocial Medicine, National Center for Child Health and Development, Tokyo, Japan.
Yuka Sano WadaDivision of Neonatology, Center for Maternal-Fetal, Neonatal, and Reproductive Medicine, National Center for Child Health and Development, Tokyo, Japan.
Naho YakuwaJapan Drug Information Institute in Pregnancy, National Center for Child Health and Development, Tokyo, Japan.
Hiroyo KawasakiDepartment of Pharmacy, National Center for Child Health and Development, Tokyo, Japan.
Tomo SuzukiDivision of Maternal Medicine, Center for Maternal-Fetal, Neonatal and Reproductive Medicine, National Center for Child Health and Development, Tokyo, Japan.
Haruhiko SagoDivision of Obstetrics, Center for Maternal-Fetal, Neonatal and Reproductive Medicine, National Center for Child Health and Development, Tokyo, Japan.
Akimasa YamataniDepartment of Pharmacy, National Center for Child Health and Development, Tokyo, Japan.
Atsuko MurashimaJapan Drug Information Institute in Pregnancy, National Center for Child Health and Development, Tokyo, Japan.
National Center For Child Health and Development · JP

Funding

National Center for Child Health and Development NCCHD2021C-5
6 · The paper itself

Abstract

backgroundA high prevalence of mental disorders including depression, anxiety, somatoform, and dissociative disorder is reported during pregnancy, however, information on the transfer of antipsychotics across the placenta and into breast milk is limited. We evaluated brotizolam, periciazine and sulpiride in cord blood, maternal serum, and breast milk, and alprazolam in breast milk. CASE PRESENTATION: A 38-year-old woman with dissociative disorder was treated with brotizolam, propericiazine, and sulpiride during pregnancy and lactation, and alprazolam during lactation. The drug concentration ratios for both cord blood and maternal serum were 33.3 and 61.5% for brotizolam and sulpiride, respectively, and periciazine (metabolite of propericiazine) was not detected in the cord blood. In breast milk, alprazolam (0.9 ng/mL), sulpiride (445.8 ng/mL), and periciazine (0.3 ng/mL) concentrations were noted at 7.5 h after the last dose on postpartum, whereas brotizolam was not detected. The relative infant doses via breast milk were 1.4, 2.7 and 0.02% of the maternal daily dose, respectively. The neonate had no congenital anomalies and did not experience any severe withdrawal symptoms after birth.

conclusionUse of brotizolam, propericiazine, and sulpiride during pregnancy and lactation, and use of alprazolam during lactation were acceptable in this case.

Indexed as

LactationPregnancyPsychiatryPsychotherapy

Identifiers

PMID35361275
PMCPMC8973510
OpenAlexW4220936592

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.