Evidence map›Paper›PMID 35361165›Full record

ArticleBMC pediatrics2022

Associations between infant growth and pubertal onset timing in a multiethnic prospective cohort of girls.

Sara Aghaee, Charles P Quesenberry, Julianna Deardorff, Lawrence H Kushi, Louise C Greenspan, Assiamira Ferrara, Ai Kubo

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC pediatrics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Sara AghaeeKaiser Permanente Northern California Division of Research, 2000 Broadway, Oakland, CA, 94612, USA.
Charles P QuesenberryKaiser Permanente Northern California Division of Research, 2000 Broadway, Oakland, CA, 94612, USA.
Julianna DeardorffDivision of Maternal and Child Health, University of California, School of Public Health, 2121 Berkeley Way #5302, Berkeley, CA, 94720, USA.
Lawrence H KushiKaiser Permanente Northern California Division of Research, 2000 Broadway, Oakland, CA, 94612, USA.
Louise C GreenspanKaiser Permanente San Francisco Medical Center, 2425 Geary Boulevard, San Francisco, CA, 94115, USA.
Assiamira FerraraKaiser Permanente Northern California Division of Research, 2000 Broadway, Oakland, CA, 94612, USA.
Ai KuboKaiser Permanente Northern California Division of Research, 2000 Broadway, Oakland, CA, 94612, USA. ai.kubo@kp.org.

Funding

Sex and Race/Ethnicity-specific Multilevel Factors Influencing Pubertal Trajectories: a Population-based StudyR01HD098220 · NICHD · KAISER FOUNDATION RESEARCH INSTITUTE · PI KUBO, AI · 2019 to 2022
$2.5M
Early Life Determinants of Accelerated Pubertal Development in Adolescent GirlsK07CA166143 · NCI · KAISER FOUNDATION RESEARCH INSTITUTE · PI KUBO, AI · 2013 to 2017
$985k
NCI NIH HHS K07 CA166143NICHD NIH HHS R01 HD098220
6 · The paper itself

Abstract

backgroundEarly puberty increases risk of adverse health conditions throughout the life course. US girls are experiencing earlier puberty without clear reasons. Studies suggest early life factors, such as infant growth, may influence pubertal timing. We assessed the associations between infant growth and onset of breast development (thelarche), pubic hair development (pubarche), and menarche in girls.

methodsA prospective cohort of girls born at a Kaiser Permanente Northern California medical facility in 2005-11 was used. Weight-for-age z-scores were calculated at birth and 24 months. Difference in z-scores greater than 0.67 represent rapid "catch-up" growth, less than -0.67 represent delayed "catch-down" growth, and between -0.67 and 0.67 represent "normal" growth. Pubertal onset was measured using clinician-assessed sexual maturity ratings (SMRs) and defined as the age at transition from SMR 1 to SMR 2 + for both thelarche and pubarche. SMR data was collected through June 2020. Menarche was analyzed as a secondary outcome. Weibull and modified Poisson regression models were used. Models were adjusted for potential confounders.

resultsThere were 15,196 girls included in the study. Approximately 30.2% experienced catch-up growth, 25.8% experienced catch-down growth, and 44% had normal growth. Girls with catch-up growth had increased risk of earlier thelarche (hazard ratio = 1.26, 95% confidence interval (CI): 1.18, 1.35), pubarche (1.38, 95% CI: 1.28, 1.48), and menarche (< 12y, relative risk = 1.52, 95% CI: 1.36, 1.69) compared to those with normal growth, after adjusting for covariates. These associations were partially mediated by childhood body mass index. Catch-down growth was associated with later pubertal onset.

conclusionsGirls who experience infant catch-up growth have higher risk of earlier pubertal development compared to girls with normal growth and the associations are partially explained by childhood obesity. This information may help clinicians to monitor girls who are at high risk of developing earlier.

Indexed as

Pediatric ObesityPubertyChildChild, PreschoolCohort StudiesFemaleHumansInfant, NewbornMenarcheProspective StudiesAdolescent healthChildhood overweightInfant developmentPuberty

Identifiers

PMID35361165
PMCPMC8969386

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.