ArticleBMC cardiovascular disorders2022
Comparison of fibrosing mediastinitis patients with vs. without markedly increased systolic pulmonary arterial pressure: a single-center retrospective study.
Article in BMC cardiovascular disorders, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 5 citations in OpenAlex.
- Clinical Features and Survival in Fibrosing Mediastinitis: A Multicenter Cohort Study.Respiration; international review of thoracic diseases · 2026Article
- The value of echocardiographic left ventricular rotational body volume analysis in the assessment of patients with pulmonary hypertension.Quantitative imaging in medicine and surgery · 2025Article
- Ultrasound-guided transbronchial biopsy in the diagnosis of fibrosing mediastinitis-associated pulmonary hypertension.Orphanet journal of rare diseases · 2025Article
- Image Findings from Dual-phase Computed Tomography Pulmonary Angiography for Diagnosing Tuberculosis-associated Fibrosing Mediastinitis.Current medical imaging · 2025Article
- Pulmonary vascular stenosis scoring in fibrosing mediastinitis.European heart journal. Imaging methods and practice · 2024Article
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Authors and funding
10 authors at 2 institutions in 1 country.
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Abstract
introductionFibrosing mediastinitis (FM) complicated with pulmonary hypertension (PH) has been considered as an important cause of morbidity and mortality. This study was designed to observe the possible effects of abnormal hemodynamics on patients by conducting a between-group comparison according to the presence of markedly increased systolic pulmonary arterial pressure (SPAP), so as to provide more information for clinical management. MATERIALS AND
methodsFifty-one patients with clinically diagnosed FM were divided in two groups (SPAP < 50 mmHg group; SPAP ≥ 50 mmHg group) and retrospectively included in the study. Data mainly including demographic factors, echocardiographic data, results of right heart catheter and computed tomography (CT) examination were retrieved from the medical database. Echocardiographic parameters pre- and post- balloon pulmonary angioplasty (BPA) treatment were also collected in 8 patients.
resultsSignificant changes in cardiac structure, hemodynamics and cardiac function were detected in patients complicated with markedly increased SPAP. Patients in the SPAP ≥ 50 mmHg group had increased right heart diameter, right heart ratio and velocity of tricuspid regurgitation (VTR) (p < 0.05). Deteriorated right heart function was also observed. There was no significant difference in CT findings between the two groups, except that more patients in the SPAP ≥ 50 mmHg group had pleural effusion (p < 0.05). After primary BPA in 8 patients, improvement in the right atrium proportion was observed.
conclusionsChanges due to significantly increased SPAP in patients with FM include adverse structure and function of the right heart, but differences in CT findings were not significant. Echocardiography has advantages as a noninvasive tool for the evaluation of cardiac structure, function and hemodynamics in patients with FM.
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