Evidence map›Paper›PMID 35361039›Full record

ArticleJournal of enzyme inhibition and medicinal chemistry2022

Design, synthesis and biological evaluation of novel

Maja Przybyłowska, Krystyna Dzierzbicka, Szymon Kowalski, Sebastian Demkowicz, Mateusz Daśko, Iwona Inkielewicz-Stepniak

Abstract read
In one paragraph

Article in Journal of enzyme inhibition and medicinal chemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Tacrine-Based Hybrids: Past, Present, and Future.International journal of molecular sciences · 2023
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Maja PrzybyłowskaDepartment of Organic Chemistry, Gdansk University of Technology, Gdansk, Poland.ORCID 0000-0002-8228-9359
Krystyna DzierzbickaDepartment of Organic Chemistry, Gdansk University of Technology, Gdansk, Poland.ORCID 0000-0003-2447-8095
Szymon KowalskiDepartment of Pharmaceutical Pathophysiology, Faculty of Pharmacy, Medical University of Gdansk, Gdansk, Poland.ORCID 0000-0001-6539-9161
Sebastian DemkowiczDepartment of Organic Chemistry, Gdansk University of Technology, Gdansk, Poland.ORCID 0000-0002-4252-4297
Mateusz DaśkoDepartment of Inorganic Chemistry, Gdansk University of Technology, Gdansk, Poland.ORCID 0000-0002-3367-6491
Iwona Inkielewicz-StepniakDepartment of Pharmaceutical Pathophysiology, Faculty of Pharmacy, Medical University of Gdansk, Gdansk, Poland.ORCID 0000-0003-1676-2723

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this work, we designed, synthesised and biologically investigated a novel series of 14

Indexed as

Alzheimer DiseaseTacrineAcetylcholinesteraseCholinesterase InhibitorsHumansStructure-Activity RelationshipAcetylcholinesteraseCholinesterase InhibitorsTacrineAlzheimer’s diseasecholinesterase inhibitory activityhepatotoxicitymolecular dockingneurotoxicityphosphorus tacrine analogstacrine

Identifiers

PMID35361039
PMCPMC8979514

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.