Evidence map›Paper›PMID 35360988›Full record

Observational studyThe journal of vascular access2023

Central venous catheter-related complications in older haemodialysis patients: A multicentre observational cohort study.

Mathijs van Oevelen, Boudewijn Dc Heggen, Alferso C Abrahams, Joris I Rotmans, Maarten Gj Snoeijs, Robin Wm Vernooij, Marjolijn van Buren, Sabine Ca Meijvis

Open access · hybridAbstract readObservational StudyMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in The journal of vascular access, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Observational
  2. Review
  3. Dialysis in the Elderly: A Practical Guide for the Clinician.International journal of nephrology · 2025
    Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Mathijs van OevelenDepartment of Internal Medicine, Leiden University Medical Center, Leiden, The Netherlands.ORCID 0000-0002-7459-9656
Boudewijn Dc HeggenDepartment of Vascular Surgery, Maastricht University Medical Center, Maastricht, The Netherlands.
Alferso C AbrahamsDepartment of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, The Netherlands.
Joris I RotmansDepartment of Internal Medicine, Leiden University Medical Center, Leiden, The Netherlands.ORCID 0000-0001-9682-6234
Maarten Gj SnoeijsDepartment of Vascular Surgery, Maastricht University Medical Center, Maastricht, The Netherlands.
Robin Wm VernooijDepartment of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, The Netherlands.
Marjolijn van BurenDepartment of Internal Medicine, Leiden University Medical Center, Leiden, The Netherlands.
Sabine Ca MeijvisDepartment of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, The Netherlands.
Leiden University Medical Center · NLMaastricht University · NLUniversity Medical Center Utrecht · NLUtrecht University · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCentral venous catheters (CVC) remain a commonly used vascular access option in haemodialysis, despite guidelines advising to preferably use arteriovenous fistulae. Compared to younger patients, the risk-benefit ratio of CVC in older patients might be more beneficial, but previous studies mainly focussed on catheter-related bacteraemia and/or assessed tunnelled CVC (TCVC) only. This study's aim was to compare all catheter-related infections and malfunctions in older patients with younger patients using all CVC subtypes. MATERIALS AND

methodsWe used data from DUCATHO, a multicentre observational cohort study in The Netherlands. All adult patients in whom a CVC was placed for haemodialysis between 2012 and 2016 were included. The primary endpoint was the occurrence of catheter-related infections, comparing patients aged ⩾70 years with patients aged <70 years (reference). As secondary endpoints, catheter malfunctions and catheter removal due to either infection or malfunction were assessed. Using Cox proportional hazards and recurrent events modelling, hazard ratios (HR) with 95% confidence intervals (CI) were calculated with adjustment of prespecified confounders. Additionally, endpoints were assessed for non-tunnelled CVC (NTCVC) and TCVC separately.

resultsA total of 1595 patients with 2731 CVC (66.5% NTCVC, 33.1% TCVC) were included. Of these patients, 1001 (62.8%) were aged <70 years and 594 (37.2%) ⩾70 years. No statistically significant difference was found for the occurrence of catheter-related infections (adjusted HR 0.80-95% CI 0.62-1.02), catheter malfunction (adjusted HR 0.94-95% CI 0.75-1.17) and catheter removal due to infection or malfunction (adjusted HR 0.94-95% CI 0.80-1.11). Results were comparable when assessing NTCVC and TCVC separately.

conclusionPatients aged ⩾70 to <70 years have a comparable risk for the occurrence of catheter-related infections and catheter malfunction. These findings may help when discussing treatment options with older patients starting haemodialysis and may inform the current debate on the best vascular access for these patients.

Indexed as

Catheterization, Central VenousCatheter-Related InfectionsCentral Venous CathetersAgedCohort StudiesCysteineHumansRenal DialysisCysteineS-(1,2,2-trichlorovinyl)-L-cysteinecathetercomplicationelderlyHaemodialysisinfectionvascular access

Identifiers

PMID35360988
PMCPMC10714686
OpenAlexW4220999112

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.