Evidence map›Paper›PMID 35360926›Full record

ArticleStroke2022

Longitudinal Progression of Magnetic Resonance Imaging Markers and Cognition in Dutch-Type Hereditary Cerebral Amyloid Angiopathy.

Suzanne E van Dijk, Jeroen van der Grond, Jessie Lak, Annette van den Berg-Huysmans, Gerda Labadie, Gisela M Terwindt, Marieke J H Wermer, M Edip Gurol, Mark A van Buchem, Steven M Greenberg and 1 more

Erratum issuedOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stroke, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Article
  3. Neurovascular coupling in early stage dementia - A case-control study.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024
    Article
  4. Review
  5. Microstructural white matter integrity in relation to vascular reactivity in Dutch-type hereditary cerebral amyloid angiopathy.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Suzanne E van DijkDepartment of Radiology (S.E.v.D., J.v.d.G., J.L., A.v.d.B-H, G.L., M.A.v.B., S.v.R), Leiden University Medical Center, Leiden, the Netherlands.ORCID 0000-0003-1957-1746
Jeroen van der GrondDepartment of Radiology (S.E.v.D., J.v.d.G., J.L., A.v.d.B-H, G.L., M.A.v.B., S.v.R), Leiden University Medical Center, Leiden, the Netherlands.
Jessie LakDepartment of Radiology (S.E.v.D., J.v.d.G., J.L., A.v.d.B-H, G.L., M.A.v.B., S.v.R), Leiden University Medical Center, Leiden, the Netherlands.
Annette van den Berg-HuysmansDepartment of Radiology (S.E.v.D., J.v.d.G., J.L., A.v.d.B-H, G.L., M.A.v.B., S.v.R), Leiden University Medical Center, Leiden, the Netherlands.
Gerda LabadieDepartment of Radiology (S.E.v.D., J.v.d.G., J.L., A.v.d.B-H, G.L., M.A.v.B., S.v.R), Leiden University Medical Center, Leiden, the Netherlands.
Gisela M TerwindtDepartment of Neurology (G.M.T., M.J.H.W.), Leiden University Medical Center, Leiden, the Netherlands.ORCID 0000-0003-3140-6882
Marieke J H WermerDepartment of Neurology (G.M.T., M.J.H.W.), Leiden University Medical Center, Leiden, the Netherlands.ORCID 0000-0002-6838-9521
M Edip GurolDepartment of Neurology, Massachusetts General Hospital, Boston (M.E.G., S.M.G.).ORCID 0000-0002-2169-4457
Mark A van BuchemDepartment of Radiology (S.E.v.D., J.v.d.G., J.L., A.v.d.B-H, G.L., M.A.v.B., S.v.R), Leiden University Medical Center, Leiden, the Netherlands.ORCID 0000-0003-1881-1998
Steven M GreenbergDepartment of Neurology, Massachusetts General Hospital, Boston (M.E.G., S.M.G.).ORCID 0000-0003-1792-8887
Sanneke van RoodenDepartment of Radiology (S.E.v.D., J.v.d.G., J.L., A.v.d.B-H, G.L., M.A.v.B., S.v.R), Leiden University Medical Center, Leiden, the Netherlands.ORCID 0000-0002-1468-8403
Leiden University Medical Center · NLMassachusetts General Hospital · US

Funding

Early Detection of Cerebral Amyloid AngiopathyR01NS070834 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI GREENBERG, STEVEN M · 2010 to 2014
$2.3M
NINDS NIH HHS R01 NS070834
6 · The paper itself

Abstract

backgroundHemorrhagic and ischemic magnetic resonance imaging lesions as well as the more recently described decrease in vasomotor reactivity have been suggested as possible biomarkers for cerebral amyloid angiopathy (CAA). Analyses of these markers have been primarily cross-sectional during the symptomatic phase of the disease, with little data on their longitudinal progression, particularly in the presymptomatic phase of the disease when it may be most responsive to treatment. We used the unique opportunity provided by studying Dutch-type hereditary cerebral amyloid angiopathy (D-CAA) to determine longitudinal progression of CAA biomarkers during the presymptomatic as well as the symptomatic phase of the disease.

methodsIn this longitudinal case-control study, magnetic resonance imaging markers and cognitive performance were assessed at baseline and after ≈4 years in 10 presymptomatic and 6 symptomatic D-CAA mutation carriers and 20 control subjects. These magnetic resonance imaging markers included hemorrhagic and ischemic manifestations, measurements of cerebral blood flow, and vasomotor reactivity to visual stimulation.

resultsIn presymptomatic D-CAA mutations carriers, vasomotor reactivity showed a decline over time for blood-oxygen-level-dependent amplitude (

conclusionsOur findings indicate that in the presymptomatic phase of D-CAA, cerebrovascular reactivity measured by the blood-oxygen-level-dependent amplitude and time to peak to visual stimulation progressively worsens and can thus be regarded as a disease progression marker. In the symptomatic phase, the most salient marker of progression appears to be recurrent intracerebral hemorrhage.

Indexed as

Cerebral Amyloid AngiopathyCerebral Amyloid Angiopathy, FamilialBiomarkersCase-Control StudiesCerebral HemorrhageCognitionCross-Sectional StudiesHumansMagnetic Resonance ImagingOxygenBiomarkersOxygenbiomarkercerebral amyloid angiopathyhemorrhagemagnetic resonance imagingmutation

Identifiers

PMID35360926
PMCPMC9126261
OpenAlexW4221006356

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.