Trial reportCirculation. Cardiovascular imaging2022
Synthetic Extracellular Volume in Cardiac Magnetic Resonance Without Blood Sampling: a Reliable Tool to Replace Conventional Extracellular Volume.
Trial report in Circulation. Cardiovascular imaging, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 39 citations in OpenAlex.
- Cardiac fibrosis: mechanistic insights and translational advances.Molecular biomedicine · 2026Review
- Cardiovascular magnetic resonance for therapy monitoring in cardiomyopathies.European heart journal. Imaging methods and practice · 2026Review
- Towards fully automated synthetic ECV quantification: an open-access machine learning-based approach for fast blood draw-free CMR.Scientific reports · 2026Article
- Advanced myocardial characterization and function with cardiac CT.The international journal of cardiovascular imaging · 2026Review
- Excellent Reproducibility of Synthetic Extracellular Volume Without Blood Extraction Across Different Cardiomyopathies Using Published Regression Models.Journal of cardiovascular development and disease · 2026Article
- Differentiation of light chain cardiac amyloidosis and hypertrophic cardiomyopathy by ensemble machine learning-based radiomic analysis of cardiac magnetic resonance.Orphanet journal of rare diseases · 2025Article
- Optimizing synthetic hematocrit for cardiac MRI: a multivariable model calibrated with standardized venous sampling.The international journal of cardiovascular imaging · 2025Article
- Article
- Effects of acute hydration changes on cardiovascular magnetic resonance native T1 and T2 mapping.The international journal of cardiovascular imaging · 2025Article
- Prediction of histopathological grade in gastric cancer using dual energy CT-derived synthetic extracellular volume fraction.Frontiers in oncology · 2025Article
- Scanner-generated native T1 mapping: a novel approach for assessing myocardial fibrosis in coronary heart disease.Frontiers in cardiovascular medicine · 2025Article
- Establishment of a synthetic ECV model and its prognostic value in diabetes patients with acute myocardial infarction.Frontiers in endocrinology · 2025Article
- Additional value of cardiac magnetic resonance parametric mapping in tissue characterization of common benign paediatric cardiac tumours.European heart journal. Cardiovascular Imaging · 2024Article
- Advances in Cardiac Imaging and Genetic Testing for Diagnosis and Risk Stratification in Cardiomyopathies: 2024 Update.Journal of clinical medicine · 2024Review
- Clinical Applications of Cardiac Magnetic Resonance Parametric Mapping.Diagnostics (Basel, Switzerland) · 2024Review
- The Role of Multimodality Imaging in Cardiomyopathy.Current cardiology reports · 2024Review
- Establishment and validation of an extracellular volume model without blood sampling in ST-segment elevation myocardial infarction patients.European heart journal. Imaging methods and practice · 2024Article
- Myocardial extracellular volume quantification with computed tomography-current status and future outlook.Insights into imaging · 2023Review
- Quantification of myocardial extracellular volume without blood sampling.European heart journal. Imaging methods and practice · 2023Article
- Half-Dose versus Single-Dose Gadobutrol for Extracellular Volume Measurements in Cardiac Magnetic Resonance.Journal of cardiovascular development and disease · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 7 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe calculation of extracellular volume (ECV) in cardiac magnetic resonance requires hematocrit, limiting its applicability in clinical practice. Based on the linear relationship between hematocrit and blood T1 relaxivity, a synthetic ECV could be estimated without a blood sample. We aim to develop and test regression models for synthetic ECV without blood sampling in 1.5-T and 3.0-T scanners.
methodsA total of 1101 subjects who underwent cardiac magnetic resonance scanning with native and postcontrast T1 mapping and venous hematocrit within 24 hours were retrospectively enrolled. Subjects were randomly split into derivation (n=550) and validation (n=551) subgroups for each scanner. Different regression models were derived controlling for sex, field strength, and left ventricle/right ventricle blood pool and validated in the validation group. We performed additional validation analyses in subgroups of patients with histological validation (n=17), amyloidosis (n=29), anemia (n=185), and reduced ejection fraction (n=322).
resultsIn the derivation group, 8 specific models and 2 common estimate models were derived. In the validation group, using specific models, synthetic ECV had high agreement with conventional ECV (R
conclusionsSynthetic ECV provided a promising way to calculate ECV without blood sampling. Specific models could provide the most accurate value, while common models could be more suitable in routine clinical practice because of their simplicity while maintaining adequate accuracy.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.