Evidence map›Paper›PMID 35360887›Full record

ArticleRSC chemical biology2022

Trapping and structural characterisation of a covalent intermediate in vitamin B

Matthew J Rodrigues, Nitai Giri, Antoine Royant, Yang Zhang, Rachel Bolton, Gwyndaf Evans, Steve E Ealick, Tadhg Begley, Ivo Tews

Abstract read
In one paragraph

Article in RSC chemical biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Matthew J RodriguesBiological Sciences, Institute for Life Sciences, University of Southampton Southampton SO17 1BJ UK ivo.tews@soton.ac.uk.ORCID https://orcid.org/0000-0003-1243-903X
Nitai GiriDepartment of Chemistry, Texas A&M University College Station TX 77843 USA.ORCID https://orcid.org/0000-0002-0476-840X
Antoine RoyantUniversité Grenoble Alpes, CNRS, CEA, Institut de Biologie Structurale (IBS), CS 10090 Grenoble Cedex 9 38044 France.
Yang ZhangDepartment of Chemistry and Chemical Biology, Cornell University Ithaca NY 14853 USA.
Rachel BoltonBiological Sciences, Institute for Life Sciences, University of Southampton Southampton SO17 1BJ UK ivo.tews@soton.ac.uk.
Gwyndaf EvansDiamond Light Source, Harwell Science and Innovation Campus Didcot OX11 0DE UK.
Steve E EalickDepartment of Chemistry and Chemical Biology, Cornell University Ithaca NY 14853 USA.ORCID https://orcid.org/0000-0001-8548-112X
Tadhg BegleyDepartment of Chemistry, Texas A&M University College Station TX 77843 USA.
Ivo TewsBiological Sciences, Institute for Life Sciences, University of Southampton Southampton SO17 1BJ UK ivo.tews@soton.ac.uk.ORCID https://orcid.org/0000-0002-4704-1139

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The Pdx1 enzyme catalyses condensation of two carbohydrates and ammonia to form pyridoxal 5-phosphate (PLP)

Identifiers

PMID35360887
PMCPMC8827014

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.