ArticleFrontiers in cellular neuroscience2022
Photostimulation of Ventral Tegmental Area-Insular Cortex Dopaminergic Inputs Enhances the Salience to Consolidate Aversive Taste Recognition Memory
Article in Frontiers in cellular neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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11 citing papers in PubMed, 22 citations in OpenAlex.
- A cortical insula-orbitofrontal circuit drives stress-induced dopamine system dysfunction.Molecular psychiatry · 2026Article
- Impact of environmental enrichment on heroin-induced neuroadaptations in the insula, nucleus accumbens and ventral tegmental area.Neuropharmacology · 2026Article
- Learning-Associated Flexibility of Cortical Taste Coding Is Impaired in Shank3 Knockout Mice.bioRxiv : the preprint server for biology · 2025Article
- Distinct subpopulations of ventral pallidal cholinergic projection neurons encode valence of olfactory stimuli.Cell reports · 2024Article
- Locus Ceruleus Dynamics Are Suppressed during Licking and Enhanced Postlicking Independent of Taste Novelty.eNeuro · 2024Article
- Partner-seeking and limbic dopamine system are enhanced following social loss in male prairie voles (Microtus ochrogaster).Genes, brain, and behavior · 2023Article
- Distinct subpopulations of ventral pallidal cholinergic projection neurons encode valence of olfactory stimuli.bioRxiv : the preprint server for biology · 2023Article
- Six Decades of Dopamine Hypothesis: Is Aryl Hydrocarbon Receptor the New D2?Reports (MDPI) · 2023Review
- Experience-dependent changes in affective valence of taste in male mice.Molecular brain · 2023Article
- Transforming experiences: Neurobiology of memory updating/editing.Frontiers in systems neuroscience · 2023Review
- Dopamine activity on the perceptual salience for recognition memory.Frontiers in behavioral neuroscience · 2022Review
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Taste memory involves storing information through plasticity changes in the neural network of taste, including the insular cortex (IC) and ventral tegmental area (VTA), a critical provider of dopamine. Although a VTA-IC dopaminergic pathway has been demonstrated, its role to consolidate taste recognition memory remains poorly understood. We found that photostimulation of dopaminergic neurons in the VTA or VTA-IC dopaminergic terminals of TH-Cre mice improves the salience to consolidate a subthreshold novel taste stimulus regardless of its hedonic value, without altering their taste palatability. Importantly, the inhibition of the D1-like receptor into the IC impairs the salience to facilitate consolidation of an aversive taste recognition memory. Finally, our results showed that VTA photostimulation improves the salience to consolidate a conditioned taste aversion memory through the D1-like receptor into the IC. It is concluded that the dopamine activity from the VTA into IC is required to increase the salience enabling the consolidation of a taste recognition memory. Notably, the D1-like receptor activity into the IC is required to consolidate both innate and learned aversive taste memories but not appetitive taste memory.
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