ReviewFrontiers in physiology2022
Molecular Events of the Crossbridge Cycle Reflected in the Force-Velocity Relationship of Activated Muscle.
Review in Frontiers in physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Mathematical Comparison of Time-Based and Stroke-Based Fatigue Models in Elite Sprint Cycling: Convergence Analysis and Practical Applications.Scandinavian journal of medicine & science in sports · 2026Article
- Increasing temperatures affect thoracic muscle performance in Arctic bumblebees.Nature communications · 2025Article
- AAV-shDUX4 provides short-term benefits but limited long-term efficacy in a DUX4 mouse model of FSHD.Molecular therapy. Methods & clinical development · 2025Article
- Validation of the energetics of a Huxley muscle-tendon complex model using experimental data obtained from mouse soleus muscle.The Journal of experimental biology · 2025Article
- Load sharing between synergistic muscles characterized by a ligand-binding approach and elastography.Scientific reports · 2023Article
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Authors and funding
2 authors.
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Abstract
Muscles convert chemical energy to mechanical work. Mechanical performance of a muscle is often assessed by the muscle's ability to shorten and generate power over a range of loads or forces, characterized by the force-velocity and force-power relationships. The hyperbolic force-velocity relationship of muscle, for a long time, has been regarded as a pure empirical description of the force-velocity data. Connections between mechanical manifestation in terms of force-velocity properties and the kinetics of the crossbridge cycle have only been established recently. In this review, we describe how the model of Huxley's crossbridge kinetics can be transformed to the hyperbolic Hill equation, and link the changes in force-velocity properties to molecular events within the crossbridge cycle driven by ATP hydrolysis. This allows us to reinterpret some findings from previous studies on experimental interventions that altered the force-velocity relationship and gain further insight into the molecular mechanisms of muscle contraction under physiological and pathophysiological conditions.
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