Trial reportFrontiers in endocrinology2022
Effects of Paternal Obesity on Fetal Development and Pregnancy Complications: A Prospective Clinical Cohort Study.
Trial report in Frontiers in endocrinology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- A systematic review on the role of paternal factors in human placental development, function, and pregnancy-related disorders.Journal of assisted reproduction and genetics · 2025Pooled it
- Global and regional incidence of intrahepatic cholestasis of pregnancy: a systematic review and meta-analysis.BMC medicine · 2025Pooled it
- Article
- Environmentally-induced sperm RNAs shape placentation and fetal growth.Research square · 2026Article
- The influence of paternal preconception health on infant birth weight: A scoping review.PloS one · 2026Article
- Cardiovascular Risk During Pregnancy: Scoping Review on the Clinical Implications and Long-Term Consequences.Journal of clinical medicine · 2025Review
- Paternal Cardiometabolic Conditions and Perinatal Mortality.Paediatric and perinatal epidemiology · 2025Article
- Association of Paternal BMI and Diet During Pregnancy with Offspring Birth Measures: The STEPS Study.Nutrients · 2025Article
- Review
- Paternal peri-conceptional physical activity and the risk of congenital heart disease in offspring: A case-control study.Andrology · 2025Observational
- Paternal family history of premature atherosclerotic disease and perinatal death: A population-based cohort study.PloS one · 2025Article
- Article
- Paternal Contributions to Recurrent Pregnancy Loss: Mechanisms, Biomarkers, and Therapeutic Approaches.Medicina (Kaunas, Lithuania) · 2024Review
- Mediation analysis in longitudinal study with high-dimensional methylation mediators.Briefings in bioinformatics · 2024Article
- Obesity, a Single Pathology Influencing Both Mother and Child-A Retrospective Analysis in Hospital Settings.Journal of personalized medicine · 2024Article
- Decrease in Sperm Parameters in the 21st Century: Obesity, Lifestyle, or Environmental Factors? An Updated Narrative Review.Journal of personalized medicine · 2024Review
- Effect of Paternal Body Mass Index onThe world journal of men's health · 2024Article
- Excessive Gestational Weight Gain Alters DNA Methylation and Influences Foetal and Neonatal Body Composition.Epigenomes · 2023Article
- Developmental origins of health and disease: Impact of paternal nutrition and lifestyle.Pediatric investigation · 2023Review
- Prenatal Androgen Excess Induces Multigenerational Effects on Female and Male Descendants.Clinical medicine insights. Endocrinology and diabetes · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objectives: To evaluate the association between paternal obesity and fetal development and pregnancy complications. Study Design: This prospective cohort clinical trial analyzed data from 7683 women with singleton pregnancies. All study subjects were sequentially divided into four groups based on paternal BMI. We compared the differences in fetal growth and pregnancy complications between different paternal BMI groups by univariate logistic regression and independent t-test. Finally, the independent predictors of SGA and macrosomia were determined. Results: The incidences of preeclampsia, cesarean section, SGA, macrosomia, and postpartum hemorrhage in the paternal obesity group were significantly higher than the normal BMI group. With the increase of paternal BMI, fetal ultrasound measurement parameter, neonatal and placental weight showed an increasing trend (trend P < 0.05). However, these differences disappeared in the obese group. The test for interaction showed the effect of paternal obesity on SGA and macrosomia was significantly affected by maternal obesity. We also found paternal obesity was an independent predictor of both SGA and macrosomia. Based on the above results, we plotted the Nomograms for clinical prediction. Conclusion: Paternal obesity can affect fetal growth parameters and placental development, which has an adverse impact on pregnancy outcomes. Optimizing the paternal BMI will help improve the health of the next generation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.