Evidence map›Paper›PMID 35360057›Full record

ArticleFrontiers in endocrinology2022

Hypoxia Induces Saturated Fatty Acids Accumulation and Reduces Unsaturated Fatty Acids Independently of Reverse Tricarboxylic Acid Cycle in L6 Myotubes.

Lukas Vacek, Ales Dvorak, Kamila Bechynska, Vit Kosek, Moustafa Elkalaf, Minh Duc Trinh, Ivana Fiserova, Katerina Pospisilova, Lucie Slovakova, Libor Vitek and 2 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in endocrinology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.7field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Lukas VacekDepartment of Pathophysiology, Third Faculty of Medicine, Charles University, Prague, Czechia.
Ales DvorakInstitute of Medical Biochemistry and Laboratory Diagnostics, First Faculty of Medicine, Charles University, Prague, Czechia.
Kamila BechynskaInstitute of Food and Nutrition Analysis, Faculty of Food and Biochemical Technology, University of Chemistry and Technology in Prague, Prague, Czechia.
Vit KosekInstitute of Food and Nutrition Analysis, Faculty of Food and Biochemical Technology, University of Chemistry and Technology in Prague, Prague, Czechia.
Moustafa ElkalafDepartment of Pathophysiology, Third Faculty of Medicine, Charles University, Prague, Czechia.
Minh Duc TrinhDepartment of Pathophysiology, Third Faculty of Medicine, Charles University, Prague, Czechia.
Ivana FiserovaDepartment of Pathophysiology, Third Faculty of Medicine, Charles University, Prague, Czechia.
Katerina PospisilovaInstitute of Medical Biochemistry and Laboratory Diagnostics, First Faculty of Medicine, Charles University, Prague, Czechia.
Lucie SlovakovaDepartment of Pathophysiology, Third Faculty of Medicine, Charles University, Prague, Czechia.
Libor VitekInstitute of Medical Biochemistry and Laboratory Diagnostics, First Faculty of Medicine, Charles University, Prague, Czechia.
Jana HajslovaInstitute of Food and Nutrition Analysis, Faculty of Food and Biochemical Technology, University of Chemistry and Technology in Prague, Prague, Czechia.
Jan PolakDepartment of Pathophysiology, Third Faculty of Medicine, Charles University, Prague, Czechia.
Charles University · CZUniversity of Chemistry and Technology, Prague · CZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Obstructive sleep apnea syndrome, characterized by repetitive episodes of tissue hypoxia, is associated with several metabolic impairments. Role of fatty acids and lipids attracts attention in its pathogenesis for their metabolic effects. Parallelly, hypoxia-induced activation of reverse tricarboxylic acid cycle (rTCA) with reductive glutamine metabolism provides precursor molecules for

Indexed as

Citric Acid CycleFatty AcidsFatty Acids, UnsaturatedHumansHypoxiaMuscle Fibers, SkeletalFatty AcidsFatty Acids, UnsaturatedglutaminhypoxiaL6 myotubeslipidsobstructive sleep apneareverse TCA

Identifiers

PMID35360057
PMCPMC8963465
OpenAlexW4220857801

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.