ArticleFrontiers in cardiovascular medicine2022
A Multimodal Score Accurately Classifies Fontan Failure and Late Mortality in Adult Fontan Patients.
Article in Frontiers in cardiovascular medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effect of liver abnormalities on mortality in Fontan patients: a systematic review and meta-analysis.BMC cardiovascular disorders · 2024Pooled it
- Proteomic Remodeling in Fontan Circulation Associated with Fibrosis and Time-Dependent Immune-Metabolic Alteration.International journal of molecular sciences · 2026Article
- Failing Fontan Following Total Cavopulmonary Connection: Extracardiac Biomarkers Reveal 2 Distinct Phenotypes With Divergent Clinical Courses.Interdisciplinary cardiovascular and thoracic surgery · 2026Article
- NT-proBNP and other blood biomarkers in patients after Fontan Surgery: Prognostic, diagnostic, and management implications.International journal of cardiology. Congenital heart disease · 2026Article
- Risk Factors for Adverse Outcomes in a Fontan Population.Pediatric cardiology · 2026Article
- Untargeted Serum Proteomics in the Fontan Circulation Reveals Three Distinct Molecular Signatures of Fontan Physiology with CYB5R3 Among Key Proteins.International journal of molecular sciences · 2026Article
- Iron deficiency and reduced exercise tolerance in adult Fontan patients.Frontiers in pediatrics · 2026Article
- The fate of the Fontan circulation.European heart journal supplements : journal of the European Society of Cardiology · 2026Article
- Interventions for Fontan Pathway Obstruction in Patients Following Total Cavopulmonary Connection.Journal of clinical medicine · 2025Article
- Longitudinal changes in ventricular function and atrioventricular valve failure following cardiac morphology after Fontan procedure.Journal of thoracic disease · 2025Article
- Impact of diaphragm paralysis and its surgical interventions on outcomes after the staged Fontan procedure.Interdisciplinary cardiovascular and thoracic surgery · 2025Article
- Impact of Ventricular Dominance on Long-Term Fontan Outcomes: A 25-year Single-institution Study.The Annals of thoracic surgery · 2023Article
- Predictors of protein losing enteropathy after Fontan completion: An 8-year retrospective study at Sheikh Khalifa Medical City.Global cardiology science & practice · 2023Article
- Pregnancy Outcomes in Women after the Fontan Procedure.Journal of clinical medicine · 2023Article
- Functional hepatic deterioration determined byFrontiers in cardiovascular medicine · 2022Article
- Unifying nomenclature describing the individuals with Fontan circulation.Annals of pediatric cardiologyArticle
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objectives: Despite the outstanding success of the Fontan operation, it is a palliative procedure and a substantial number of patients experience late failure of the Fontan circulation. Clinical presentation and hemodynamic phenotypes of Fontan failure are considerably variable. While various parameters have been identified as risk factors for late Fontan failure, a feasible score to classify Fontan failure and possibly allow timely risk stratification is lacking. Here, we explored the possibility of developing a score based on hemodynamic, clinical and laboratory parameters to classify Fontan failure and mortality. Methods: We performed a retrospective study in our cohort of adult Fontan patients from two institutions [ Results: Late failure occurred at a median of 18.2 (IQR 9.1-21.1) years after Fontan completion. Mortality associated with Fontan failure was substantial (25/52, 48.1%) with freedom of death/transplantation/take-down of 64% at 5 years and 36% at 10 years after onset of Fontan failure, respectively. Patients with Fontan failure had a significantly higher median Fontan Failure Score compared to non-failing Fontan patients [8 points (IQR 5-10) vs. 2 points (IQR 1-5), Conclusion: We have developed an uncomplex yet remarkably accurate score to classify Fontan failure and late mortality in adult Fontan patients. Prospective validation and most likely refinement and calibration of the score in larger and preferably multi-institutional cohorts is required to assess its potential to predict the risk of Fontan failure and late mortality.
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