ReviewFrontiers in cardiovascular medicine2022
Late Fontan Circulatory Failure. What Drives Systemic Venous Congestion and Low Cardiac Output in Adult Fontan Patients?
Review in Frontiers in cardiovascular medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Somatic growth in single ventricle patients: A systematic review and meta-analysis.Acta paediatrica (Oslo, Norway : 1992) · 2023Pooled it
- Fontan Failure: Current State of the Art in Mechanical Circulatory Support and Transplantation.Children (Basel, Switzerland) · 2026Review
- Serum Proteomic Profiling Implicates a Dysregulated Neurohormonal-Inflammatory Axis in Post-Fontan Sinus Tachycardia.Journal of the American Heart Association · 2026Article
- Functionally Single-Ventricle Complications After Fontan Palliation-A Narrative Review.Journal of clinical medicine · 2026Review
- Percutaneous Interventions for Heart Failure in Congenital Heart Disease.Current cardiology reports · 2026Review
- Venous Measurements as Predictors of Long-Term Fontan Complications: A Single-Center Echocardiographic Study.Journal of clinical practice and research · 2026Article
- Natural Shear Wave Elastography: A Promising Tool to Assess Myocardial Stiffness in Fontan Patients.JACC. Advances · 2026Article
- Article
- Iron deficiency and reduced exercise tolerance in adult Fontan patients.Frontiers in pediatrics · 2026Article
- Exercise hemodynamics in adults with Fontan circulation assessed by noninvasive impedance cardiography.Frontiers in cardiovascular medicine · 2026Article
- Mountains and Waves: Fontan Circulation in Different Environmental Conditions.Pediatric cardiology · 2025Review
- Cardiorenal Syndrome in Adults with Congenital Heart Disease.Journal of clinical medicine · 2025Review
- Review of rhythm disturbances in patient after fontan completion: epidemiology, management, and surveillance.Frontiers in pediatrics · 2025Review
- The Fontan Circulation in Pregnancy: Hemodynamic Challenges and Anesthetic Considerations.Journal of cardiothoracic and vascular anesthesia · 2024Review
- Lymphatic failure and lymphatic interventions: Knowledge gaps and future directions for a new frontier in congenital heart disease.Seminars in pediatric surgery · 2024Review
- Left Ventricular Assist Device Implantation With Total Cavopulmonary Connection for Arrested Heart.Annals of thoracic surgery short reports · 2024Article
- Home-based long-term physical endurance and inspiratory muscle training in children and adults with Fontan circulation.Frontiers in cardiovascular medicine · 2024Article
- SCUBA Diving in Adult Congenital Heart Disease.Journal of cardiovascular development and disease · 2023Review
- Impact of liver fibrosis and nodules formation on hemodynamics in young adults after total cavopulmonary connection. A magnetic resonance study.Frontiers in cardiovascular medicine · 2022Article
- Computational fluid dynamics-driven optimization of Fontan surgery from patient-specific data: A pilot study.Annals of pediatric cardiologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Fontan circulation provides definite palliation for children born with a single anatomical or functional ventricle by diverting systemic venous blood directly to the pulmonary arteries, effectively rendering systemic venous return into portal vessels to the lung. Although this restores pulmonary blood flow and avoids the mixture of oxygenated and deoxygenated blood, it also results in elevated systemic venous pressures and low cardiac output. These are the two hallmarks of any Fontan circulation and the cause of Fontan circulatory failure later in life. We highlight the determinants of systemic venous return, its changed relationship with the pulmonary circulation, how it affects preload, and the changed role of the heart (myocardium, valves, and heart rate). By critically evaluating the components of the Fontan circulation, we hope to give some clues in how to optimize the Fontan circulation and avenues for future research.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.