ArticleFrontiers in immunology2022
Autoantibodies Against Proteins Previously Associated With Autoimmunity in Adult and Pediatric Patients With COVID-19 and Children With MIS-C.
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Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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22 citing papers in PubMed, 35 citations in OpenAlex.
- Autoantibodies in the diagnostics, prognostics and follow-up of primary biliary cholangitis.Journal of translational autoimmunity · 2026Review
- Article
- NK Cell and Monocyte Dysfunction in Multisystem Inflammatory Syndrome in Children.Journal of immunology (Baltimore, Md. : 1950) · 2024Article
- Exploring the Contrasts and Similarities of Dengue and SARS-CoV-2 Infections During the COVID-19 Era.International journal of molecular sciences · 2024Review
- Divergent autoantibody and cytokine levels in COVID-19 sepsis patients influence survival.Journal of medical virology · 2024Article
- The Spectrum of Postacute Sequelae of COVID-19 in Children: From MIS-C to Long COVID.Annual review of virology · 2024Review
- The complex landscape of immune dysregulation in multisystem inflammatory syndrome in children with COVID-19.Life medicine · 2024Review
- Article
- Inflammatory and Autoimmune Aspects of Multisystem Inflammatory Syndrome in Children (MIS-C): A Prospective Cohort Study.Viruses · 2024Article
- Severe pediatric COVID-19: a review from the clinical and immunopathophysiological perspectives.World journal of pediatrics : WJP · 2024Review
- COVID-19-Related Multi-systemic Inflammatory Syndrome in Children (MIS-C).Advances in experimental medicine and biology · 2024Review
- Evidence of a Sjögren's disease-like phenotype following COVID-19 in mice and humans.JCI insight · 2023Article
- Investigating the Relationship Between COVID-19 and Celiac Disease. A Dual Research Approach.JPGN reports · 2023Article
- B cell phenotype and serum levels of interferons, BAFF, and APRIL in multisystem inflammatory syndrome in children associated with COVID-19 (MIS-C).Molecular and cellular pediatrics · 2023Article
- Review
- Autoantibodies Neutralizing Type III Interferons Are Uncommon in Patients with Severe Coronavirus Disease 2019 Pneumonia.Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research · 2023Article
- SARS-CoV-2 infection and recovery in children: Distinct T cell responses in MIS-C compared to COVID-19.The Journal of experimental medicine · 2023Article
- NFKB2 haploinsufficiency identified via screening for IFN-α2 autoantibodies in children and adolescents hospitalized with SARS-CoV-2-related complications.The Journal of allergy and clinical immunology · 2023Article
- Immunology of Multisystem Inflammatory Syndrome after COVID-19 in Children: A Review of the Current Evidence.International journal of molecular sciences · 2023Review
- Multisystem inflammatory syndrome in children characterized by enhanced antigen-specific T-cell expression of cytokines and its reversal following recovery.Frontiers in pediatrics · 2023Article
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Authors and funding
36 authors at 13 institutions in 4 countries.
Peter D BurbeloNational Institute of Dental and Craniofacial Research, NIH, Bethesda, MD, United States.
Riccardo CastagnoliLaboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD, United States.
Chisato ShimizuDepartment of Pediatrics, Rady Children's Hospital, University of California San Diego, San Diego, CA, United States.
Ottavia M DelmonteLaboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD, United States.
Kerry DobbsLaboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD, United States.
Valentina DiscepoloDepartment of Translational Medical Science, Section of Pediatrics, University of Naples Federico II, Naples, Italy.
Andrea Lo VecchioDepartment of Translational Medical Science, Section of Pediatrics, University of Naples Federico II, Naples, Italy.
Alfredo GuarinoDepartment of Translational Medical Science, Section of Pediatrics, University of Naples Federico II, Naples, Italy.
Francesco LicciardiDivision of Pediatric Immunology and Rheumatology, Department of Public Health and Pediatric Sciences, "Regina Margherita" Children's Hospital, University of Turin, Turin, Italy.
Ugo RamenghiDivision of Pediatric Immunology and Rheumatology, Department of Public Health and Pediatric Sciences, "Regina Margherita" Children's Hospital, University of Turin, Turin, Italy.
Emma Rey-JuradoInstituto de Ciencias e Innovación en Medicina (ICIM), Clínica Alemana Universidad del Desarrollo, Santiago, Chile.
Cecilia VialInstituto de Ciencias e Innovación en Medicina (ICIM), Clínica Alemana Universidad del Desarrollo, Santiago, Chile.
Gian Luigi MarsegliaDepartment of Pediatrics, Fondazione IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy.
Amelia LicariDepartment of Pediatrics, Fondazione IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy.
Daniela MontagnaDepartment of Pediatrics, Fondazione IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy.
Camillo RossiDirezione Sanitaria, ASST Spedali Civili, Brescia, Italy.
Gina A Montealegre SanchezIntramural Clinical Management and Operations Branch (ICMOB), Division of Clinical Research NIAID, NIH, Bethesda, MD, United States.
Karyl BarronDivision of Intramural Research, National Institute of Allergy and Infectious Disease, NIH, Bethesda, MD, United States.
Blake M WarnerNational Institute of Dental and Craniofacial Research, NIH, Bethesda, MD, United States.
John A ChioriniNational Institute of Dental and Craniofacial Research, NIH, Bethesda, MD, United States.
Yazmin EspinosaHospital Roberto del Río, Santiago, Chile.
Loreani NogueraInstituto de Ciencias e Innovación en Medicina (ICIM), Clínica Alemana Universidad del Desarrollo, Santiago, Chile.
Lesia DropulicLaboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD, United States.
Meng TruongLaboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD, United States.
Dana GerstbacherPediatric Rheumatology, Stanford Children's Hospital, Stanford, CA, United States.
Sayonara MatóPediatric Infectious Diseases, Randall Children's Hospital at Legacy Emanuel, Portland, OR, United States.
John KanegayeDepartment of Pediatrics, Rady Children's Hospital, University of California San Diego, San Diego, CA, United States.
Adriana H TremouletDepartment of Pediatrics, Rady Children's Hospital, University of California San Diego, San Diego, CA, United States.
Pediatric Emergency Medicine Kawasaki Group
Eli M EisensteinDepartment of Pediatrics, Hadassah Medical Center, Faculty of Medicine, Hebrew University, Jerusalem, Israel.
Helen C SuLaboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD, United States.
Luisa ImbertiCREA Laboratory, Diagnostic Department, ASST Spedali Civili di Brescia, Brescia, Italy.
Maria Cecilia PoliInstituto de Ciencias e Innovación en Medicina (ICIM), Clínica Alemana Universidad del Desarrollo, Santiago, Chile.
Jane C BurnsDepartment of Pediatrics, Rady Children's Hospital, University of California San Diego, San Diego, CA, United States.
Luigi D NotarangeloLaboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD, United States.
Jeffrey I CohenLaboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD, United States.
National Institute of Allergy and Infectious Diseases · USUniversidad del Desarrollo · CLUniversity of California San Diego · USUniversity of Pavia · ITNational Institute of Dental and Craniofacial Research · USUniversity of Naples Federico II · ITAzienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia · ITHadassah Medical Center · ILOspedale Regina Margherita · ITHospital Roberto del Rio · CLLucile Packard Children's Hospital · USOffice of Extramural Research · USRandall Children's Hospital at Legacy Emanuel · US
Funding
Clinical Investigations of Sjogren's SyndromeZIADE000704 · NIDCR · NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH · PI WARNER, BLAKE · 2009 to 2025
$22.3MHost factors contributing to susceptibility to COVID-19 diseaseZIAAI001265 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI SU, HELEN CHUN-HUI · 2020 to 2025
$9.5MInnate Immune Activation and Endothelial Cell Dysfunction in Acute Kawasaki DiseaseR01HL140898 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BURNS, JANE C, HOFFMAN, HAROLD M · 2018 to 2022
$4.3MDiagnosing and predicting risk in children with SARS-CoV-2- related illnessR61HD105590 · NICHD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BURNS, JANE C · 2021 to 2022
$1.8MCharacterization of host immune responses to SARS-CoV-2ZIAAI001270 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI NOTARANGELO, LUIGI · 2020 to 2025
$1.2MSerologic studies of persons with COVID-19 infectionZIAAI001258 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI COHEN, JEFFREY · 2020 to 2025
$411kNHLBI NIH HHS R01 HL140898NICHD NIH HHS R61 HD105590
Abstract
The antibody profile against autoantigens previously associated with autoimmune diseases and other human proteins in patients with COVID-19 or multisystem inflammatory syndrome in children (MIS-C) remains poorly defined. Here we show that 30% of adults with COVID-19 had autoantibodies against the lung antigen KCNRG, and 34% had antibodies to the SLE-associated Smith-D3 protein. Children with COVID-19 rarely had autoantibodies; one of 59 children had GAD65 autoantibodies associated with acute onset of insulin-dependent diabetes. While autoantibodies associated with SLE/Sjögren's syndrome (Ro52, Ro60, and La) and/or autoimmune gastritis (gastric ATPase) were detected in 74% (40/54) of MIS-C patients, further analysis of these patients and of children with Kawasaki disease (KD), showed that the administration of intravenous immunoglobulin (IVIG) was largely responsible for detection of these autoantibodies in both groups of patients. Monitoring
Indexed as
Autoimmune DiseasesCOVID-19Lupus Erythematosus, SystemicAdaptor Proteins, Signal TransducingAdenosine TriphosphatasesAdultAutoantibodiesAutoantigensAutoimmunityChildHumansImmunoglobulins, IntravenousRibonucleoproteinsSystemic Inflammatory Response SyndromeAdaptor Proteins, Signal TransducingAdenosine TriphosphatasesAutoantibodiesAutoantigensImmunoglobulins, IntravenousKLHL12 protein, humanRibonucleoproteinsautoantibodiesautoimmunityCOVID-19IVIGMIS-C multisystem inflammatory syndrome in children
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