Evidence map›Paper›PMID 35359720›Full record

ArticleFrontiers in microbiology2022

Transient Antibiotic Tolerance Triggered by Nutrient Shifts From Gluconeogenic Carbon Sources to Fatty Acid.

Christopher J Hartline, Ruixue Zhang, Fuzhong Zhang

Open access · goldAbstract read
In one paragraph

Article in Frontiers in microbiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Tregs and persistentFrontiers in oral health · 2026
    Article
  5. Review
  6. (p)ppGpp mediates persister formation inFrontiers in microbiology · 2025
    Article
  7. Article
  8. Article
  9. Heterogeneous Phenotypic Responses of Antibiotic-ResistantAntibiotics (Basel, Switzerland) · 2023
    Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Christopher J HartlineDepartment of Energy, Environmental and Chemical Engineering, Washington University in St. Louis, Saint Louis, MO, United States.
Ruixue ZhangDepartment of Energy, Environmental and Chemical Engineering, Washington University in St. Louis, Saint Louis, MO, United States.
Fuzhong ZhangDepartment of Energy, Environmental and Chemical Engineering, Washington University in St. Louis, Saint Louis, MO, United States.
Washington University in St. Louis · US

Funding

Supplement for Purchase of a Cell Sorter for R35GM133797R35GM133797 · NIGMS · WASHINGTON UNIVERSITY · PI ZHANG, FUZHONG · 2019 to 2023
$2.2M
NIGMS NIH HHS R35 GM133797
6 · The paper itself

Abstract

Nutrient shifts from glycolytic-to-gluconeogenic carbon sources can create large sub-populations of extremely antibiotic tolerant bacteria, called persisters. Positive feedback in

Indexed as

antibiotic tolerancebacterial metabolismfatty acid pathwaymetabolic positive feedbacknutrient shiftpersistence

Identifiers

PMID35359720
PMCPMC8963472
OpenAlexW4221024375

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.