ArticleFrontiers in neurology2022
White Matter Abnormalities and Cognitive Deficit After Mild Traumatic Brain Injury: Comparing DTI, DKI, and NODDI.
Article in Frontiers in neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- The second decade of DTI in TBI part 1: a systematic review of mild TBI.Frontiers in neurologyPooled it
- Continuum of Irreversible and Potentially Reversible Traumatic Brain Injury Sequelae: Axonal Injury and Hydrocephalus.Korean journal of neurotrauma · 2026Review
- Good vibrations: Sternal vibration enhances white matter density and interoceptive awareness.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- The Role of MRI in Debunking the Fallacy of "Mild" Traumatic Brain Injury.Journal of magnetic resonance imaging : JMRI · 2026Review
- Feasibility of neurite oriented diffusion and density imaging in thigh skeletal muscle of volunteers with knee pain: relationship with proton density fat fraction: a cross-sectional study.BMC medical imaging · 2026Article
- Neurite orientation dispersion and density imaging in stroke: current applications, limitations, and future directions.Frontiers in human neuroscience · 2026Review
- Multimodal diffusion MRI biomarkers of white matter alterations and clinical impairment in mTBI.Frontiers in neuroscience · 2026Article
- Good vibrations: Sternal vibration enhances white matter density and interoceptive awareness.Research square · 2025Article
- Neurite orientation dispersion and density imaging reveals microstructural damage in moyamoya disease: a study based on tract- and gray-based spatial statistics.BMC medical imaging · 2025Article
- ISMRM Clinical Focus Meeting 2023: "Imaging the Fire in the Brain".Journal of magnetic resonance imaging : JMRI · 2025Article
- Quantified Head-Ball Impacts in Soccer: A Preliminary, Prospective Study.Neurotrauma reports · 2025Article
- Altered white matter microstructural integrity in patients with postherpetic neuralgia: a combined DTI and DTI-NODDI study.Frontiers in neuroscience · 2025Article
- Brain white matter development in 8-year-old children is associated with maternal mental health during pregnancy.Frontiers in human neuroscience · 2025Article
- White matter changes in recovered COVID-19 patients: insights from DTI, DKI, and NODDI metrics.Frontiers in neurology · 2025Article
- Microstructural changes of the white matter in systemic lupus erythematosus patients without neuropsychiatric symptoms: a multi-shell diffusion imaging study.Arthritis research & therapy · 2024Article
- Predicting Alzheimer's progression in MCI: a DTI-based white matter network model.BMC medical imaging · 2024Article
- White Matter Alterations in Military Service Members With Remote Mild Traumatic Brain Injury.JAMA network open · 2024Article
- Associations of prior concussion severity with brain microstructure using mean apparent propagator magnetic resonance imaging.Human brain mapping · 2024Article
- Multi-tensor fixel-based metrics in tractometry: application to multiple sclerosis.Frontiers in neuroscience · 2024Article
- White matter microstructural disruption in minimal hepatic encephalopathy: a neurite orientation dispersion and density imaging (NODDI) study.Neuroradiology · 2023Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
White matter (WM) disruption is an important determinant of cognitive impairment after mild traumatic brain injury (mTBI), but traditional diffusion tensor imaging (DTI) shows some limitations in assessing WM damage. Diffusion kurtosis imaging (DKI) and neurite orientation dispersion and density imaging (NODDI) show advantages over DTI in this respect. Therefore, we used these three diffusion models to investigate complex WM changes in the acute stage after mTBI. From 32 mTBI patients and 31 age-, sex-, and education-matched healthy controls, we calculated eight diffusion metrics based on DTI (fractional anisotropy, axial diffusivity, radial diffusivity, and mean diffusivity), DKI (mean kurtosis), and NODDI (orientation dispersion index, volume fraction of intracellular water (Vic), and volume fraction of the isotropic diffusion compartment). We used tract-based spatial statistics to identify group differences at the voxel level, and we then assessed the correlation between diffusion metrics and cognitive function. We also performed subgroup comparisons based on loss of consciousness. Patients showed WM abnormalities and cognitive deficit. And these two changes showed positive correlation. The correlation between Vic of the splenium of the corpus callosum and Digit Symbol Substitution Test scores showed the smallest
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