ArticleBiological psychiatry. Cognitive neuroscience and neuroimaging2023
Cross-sectional and Longitudinal Associations of Anxiety and Irritability With Adolescents' Neural Responses to Cognitive Conflict.
Article in Biological psychiatry. Cognitive neuroscience and neuroimaging, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
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Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 17 citations in OpenAlex.
- Understanding irritability through the lens of self-regulatory control processes in children and adolescents: a systematic review.European child & adolescent psychiatry · 2025Pooled it
- Scoping review of precision child and youth mental health research: dwelling in possibility.Frontiers in psychiatry · 2025Pooled it
- Neural responses to error in youth: the impact of social context, anxiety, and worry.European child & adolescent psychiatry · 2026Article
- Inhibition-related connectivity predicts irritability risk and resilience across early adolescence.Social cognitive and affective neuroscience · 2026Article
- Adolescent cognitive control processing is associated with anxiety in young adulthood during the COVID-19 pandemic.Cognitive, affective & behavioral neuroscience · 2025Article
- Neural Correlates of Irritability and Potential Moderating Effects of Inhibitory Control.Biological psychiatry global open science · 2025Article
- Leveraging technology to probe mechanisms of psychopathology: A proof of concept study of inhibitory control.PloS one · 2025Article
- Error-related brain activity shapes the association between trait neuroticism and internalizing symptomatology in two tasks.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2024Article
- Neural mechanisms of inhibitory control in preadolescent irritability: Insights from the ABCD study.Biological psychology · 2024Article
- Autistic Symptoms, Irritability, and Executive Dysfunctions: Symptom Dynamics from Multi-Network Models.Journal of autism and developmental disorders · 2024Article
- Current and Future Approaches to Pediatric Anxiety Disorder Treatment.The American journal of psychiatry · 2024Review
- Neural sensitivity following stress predicts anhedonia symptoms: a 2-year multi-wave, longitudinal study.Translational psychiatry · 2024Article
- Multimodal study of the neural sources of error monitoring in adolescents and adults.Psychophysiology · 2023Article
- Neural Sensitivity following Stress Predicts Anhedonia Symptoms: A 2-Year Multi-wave, Longitudinal Study.Research square · 2023Article
- Executive Functioning Constructs in Anxiety, Obsessive-Compulsive, Post-Traumatic Stress, and Related Disorders.Current psychiatry reports · 2022Review
Corrections and comments
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Authors and funding
15 authors at 3 institutions in 3 countries.
Funding
Abstract
backgroundPsychiatric symptoms are commonly comorbid in childhood. The ability to disentangle unique and shared correlates of comorbid symptoms facilitates personalized medicine. Cognitive control is implicated broadly in psychopathology, including in pediatric disorders characterized by anxiety and irritability. To disentangle cognitive control correlates of anxiety versus irritability, the current study leveraged both cross-sectional and longitudinal data from early childhood into adolescence.
methodsFor this study, 89 participants were recruited from a large longitudinal research study on early-life temperament to investigate associations of developmental trajectories of anxiety and irritability symptoms (from ages 2 to 15) as well as associations of anxiety and irritability symptoms measured cross-sectionally at age 15 with neural substrates of conflict and error processing assessed at age 15 using the flanker task.
resultsResults of whole-brain multivariate linear models revealed that anxiety at age 15 was uniquely associated with decreased neural response to conflict across multiple regions implicated in attentional control and conflict adaptation. Conversely, irritability at age 15 was uniquely associated with increased neural response to conflict in regions implicated in response inhibition. Developmental trajectories of anxiety and irritability interacted in relation to neural responses to both error and conflict.
conclusionsOur findings suggest that neural correlates of conflict processing may relate uniquely to anxiety and irritability. Continued cross-symptom research on the neural correlates of cognitive control could stimulate advances in individualized treatment for anxiety and irritability during child and adolescent development.
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