ArticleInternational journal of cardiology2022
NT-proBNP and predictors of event free survival and left ventricular systolic function recovery in peripartum cardiomyopathy.
Article in International journal of cardiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 12 citations in OpenAlex.
- Article
- Identifying new blood biomarkers of neuroplasticity associated with rehabilitation outcomes after stroke.Scientific reports · 2025Observational
- The association of heart rate with adverse outcomes and recurrent heart failure hospitalization in peripartum cardiomyopathy.Clinical research in cardiology : official journal of the German Cardiac Society · 2025Article
- Diagnosis and management of peripartum cardiomyopathy and recurrence risk.International journal of cardiology. Congenital heart disease · 2024Article
- Clinical predictors of right ventricular dysfunction and association with adverse outcomes in peripartum cardiomyopathy.ESC heart failure · 2024Article
- Biomarkers in Peripartum Cardiomyopathy-What We Know and What Is Still to Be Found.Biomolecules · 2024Review
- The Utilization and Interpretation of Cardiac Biomarkers During Pregnancy:JACC. Advances · 2022Review
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Authors and funding
16 authors at 8 institutions in 1 country.
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Abstract
objectiveTo determine predictors of adverse outcomes in peripartum cardiomyopathy (PPCM). METHODS AND
resultsWe conducted a multi-center cohort study across four centers to identify subjects with PPCM with the following criteria: LVEF <40%, development of heart failure within the last month of pregnancy or within 5 months of delivery and no other identifiable cause of heart failure with reduced ejection fraction. Outcomes included 1) survival free from major adverse events (need for extra-corporeal membrane oxygenation, ventricular assist device, orthotopic heart transplantation or death) and 2) LVEF recovery ≥ 50%. Using a univariate logistic regression analysis, we identified significant clinical predictors of these outcomes, which were then used to create multivariable models. NT-proBNP at the time of diagnosis was examined both as a continuous variable (log transformed) in logistic regression and as a dichotomous variable (values above and below the median) using the log-rank test. In all, 237 women (1993 to 2017) with 736.4 person-years of follow-up, met criteria for PPCM. Participants had a mean age of 32.4 ± 6.7 years, mean BMI 30.6 ± 7.8 kg/m2; 63% were White. After median follow-up of 3.6 years (IQR 1.1-7.8), 113 (67%) had LVEF recovery, and 222 (94%) had survival free from adverse events. Significant predictors included gestational age, gravidity, systolic blood pressure, smoking, heart rate, initial LVEF, and diuretic use. In a subset of 110 patients with measured NTproBNP levels, we found a higher event free survival for women with NTproBNP <2585 pg/ml (median) as compared to women with NTproBNP ≥2585 pg/ml (log-rank test p-value 0.018).
conclusionGestational age, gravidity, current or past tobacco use, systolic blood pressure, heart rate, initial LVEF and diuretic requirement at the time of diagnosis were associated with survival free from adverse events and LVEF recovery. Initial NT-proBNP was significantly associated with event free survival.
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