Evidence map›Paper›PMID 35358541›Full record

ArticleEnvironmental research2022

Associations between APOL1 genetic variants and blood pressure in African American mothers and children from a U.S. pregnancy cohort: Modification by air pollution exposures.

Yu Ni, Claire L Simpson, Robert L Davis, Adam A Szpiro, Catherine J Karr, Csaba P Kovesdy, Rebecca C Hjorten, Frances A Tylavsky, Nicole R Bush, Kaja Z LeWinn and 3 more

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In one paragraph

Article in Environmental research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.1field-weighted citation impact, top 56% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 1 country.

Yu NiDepartment of Environmental and Occupational Health Sciences, School of Public Health, University of Washington, Seattle, WA, USA. Electronic address: niyu@uw.edu.
Claire L SimpsonDepartment of Genetics, Genomics and Informatics, College of Medicine, University of Tennessee Health Science Center, Memphis, TN, USA.
Robert L DavisCenter for Biomedical Informatics, University of Tennessee Health Science Center, Memphis, TN, USA; Department of Pediatrics, College of Medicine, University of Tennessee Health Science Center, Memphis, TN, USA.
Adam A SzpiroDepartment of Biostatistics, School of Public Health, University of Washington, Seattle, WA, USA.
Catherine J KarrDepartment of Environmental and Occupational Health Sciences, School of Public Health, University of Washington, Seattle, WA, USA; Department of Pediatrics, School of Medicine, University of Washington, Seattle, WA, USA; Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA, USA.
Csaba P KovesdyDivision of Nephrology, University of Tennessee Health Science Center, Memphis, TN, USA; Nephrology Section, Memphis VA Medical Center, Memphis, TN, USA.
Rebecca C HjortenPediatrics Division of Nephrology, Seattle Children's Hospital, Seattle, WA, USA.
Frances A TylavskyDepartment of Preventive Medicine, University of Tennessee Health Science Center, Memphis, TN, USA.
Nicole R BushDepartment of Psychiatry and Behavioral Sciences, School of Medicine, University of California, San Francisco, San Francisco, CA, USA; Department of Pediatrics, School of Medicine, University of California, San Francisco, San Francisco, CA, USA.
Kaja Z LeWinnDepartment of Psychiatry and Behavioral Sciences, School of Medicine, University of California, San Francisco, San Francisco, CA, USA.
Cheryl A WinklerBasic Research Laboratory, Molecular Genetic Epidemiology Section, Frederick National Laboratory for Cancer Research, National Cancer Institute, Frederick, MD, USA.
Jeffrey B KoppKidney Disease Section, Kidney Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.
Yoshitsugu ObiDivision of Nephrology, Department of Medicine, University of Mississippi Medical Center, Jackson, MS, USA; Department of Medicine-Nephrology, University of Tennessee Health Science Center, Memphis, TN, USA.
University of Tennessee Health Science Center · USUniversity of Washington · USUniversity of California, San Francisco · USFrederick National Laboratory for Cancer Research · USNational Institutes of Health · USSeattle Children's Hospital · US

Funding

XENOBIOTIC BIOTRANSFORMATION AND DISPOSITIONP30ES007033 · NIEHS · UNIVERSITY OF WASHINGTON · PI Nicole Ann Errett · 1995 to 2026
$42.5M
Tracking and Evaluation CoreU54GM115428 · NIGMS · UNIVERSITY OF MISSISSIPPI MED CTR · PI GOMEZ-SANCHEZ, CELSO ENRIQUE · 2016 to 2025
$38.2M
Prenatal and Early Childhood Pathways To Health:  An Integrated Model of Chemical and Social Exposures, Biological Mechanisms, and Sex-Specific Effects on Neurodevelopment and Respiratory OutcomesUH3OD023271 · OD · UNIVERSITY OF WASHINGTON · PI BUSH, NICOLE RENEE, KARR, CATHERINE J · 2018 to 2022
$37.3M
Focal Segmental Glomerulosclerosis: Genetics & MechanismsZIADK043308 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI KOPP, JEFFREY BURNETT · 2009 to 2024
$15.7M
Urban Air Pollution and Pathological Brain Aging: A Nationwide Twin Study in MenP01AG055367 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI MACK, WILLIAM J · 2018 to 2022
$11.5M
Genetics of Renal Disease in African AmericansZIABC010022 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI WINKLER, CHERYL · 2009 to 2022
$8.9M
Focal segmental glomerulosclerosis: TreatmentZIADK043412 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI KOPP, JEFFREY BURNETT · 2009 to 2024
$7.4M
Focal segmental glomerulosclerosis: HIV-associated nephropathyZIADK043411 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI HEYMANN, JURGEN · 2009 to 2024
$7.3M
Identification of Genetic Factors Associated with Infectious DiseasesZIABC010297 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI WINKLER, CHERYL · 2009 to 2022
$6.3M
Prenatal and Early Childhood Pathways To Health:  An Integrated Model of Chemical and Social Exposures, Biological Mechanisms, and Sex-Specific Effects on Neurodevelopment and Respiratory OutcomesUG3OD023271 · OD · UNIVERSITY OF WASHINGTON · PI BUSH, NICOLE RENEE, KARR, CATHERINE J · 2016 to 2017
$5.1M
Pregnancy Folate Status & Early Childhood Respiratory & Atopic Disease OutcomesR01HL109977 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI CARROLL, KECIA NICOLE · 2011 to 2015
$3.4M
SPIROMICS - Air Pollution StudyR01ES023500 · NIEHS · JOHNS HOPKINS UNIVERSITY · PI HANSEL, NADIA N, KAUFMAN, JOEL DANIEL · 2014 to 2018
$3.2M
EPA RD838300NHLBI NIH HHS R01 HL109977NIA NIH HHS P01 AG055367NIEHS NIH HHS P30 ES007033NIEHS NIH HHS R01 ES023500NIEHS NIH HHS R01 ES025888NIEHS NIH HHS R56 ES026528NIGMS NIH HHS U54 GM115428NIH HHS UG3 OD023271NIH HHS UH3 OD023271
6 · The paper itself

Abstract

introductionCarriage of high-risk APOL1 genetic variants is associated with increased risks for kidney diseases in people of African descent. Less is known about the variants' associations with blood pressure or potential moderators.

methodsWe investigated these associations in a pregnancy cohort of 556 women and 493 children identified as African American. Participants with two APOL1 risk alleles were defined as having the high-risk genotype. Blood pressure in both populations was measured at the child's 4-6 years visit. We fit multivariate linear and Poisson regressions and further adjusted for population stratification to estimate the APOL1-blood pressure associations. We also examined the associations modified by air pollution exposures (particulate matter ≤2.5 μ m in aerodynamic diameter [PM

resultsNeither APOL1 risk alleles nor risk genotypes had a main effect on blood pressure in mothers or children. However, each 2-μg/m

conclusionThis study sheds light on the distribution of high blood pressure by APOL1 genetic variants and informs regulatory policy to protect vulnerable population subgroups.

Indexed as

Air PollutionApolipoprotein L1HypertensionBlack or African AmericanBlood PressureChildChild, PreschoolFemaleGenotypeHumansMaleMothersParticulate MatterPregnancyAPOL1 protein, humanApolipoprotein L1Particulate MatterAir pollution exposuresAPOL1 genetic variantsBlood pressureChild healthGene–environment interactionHypertension

Identifiers

PMID35358541
PMCPMC9233157
OpenAlexW4220683602

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.