Evidence map›Paper›PMID 35358395›Full record

Trial reportApplied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme2022

A single dose of dietary nitrate supplementation protects against endothelial ischemia-reperfusion injury in early postmenopausal women.

Y B Somani, R N Soares, J Gosalia, J M Delgado, M Flanagan, S Basu, D B Kim-Shapiro, J M Murias, D N Proctor

Open access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 2 pooled it
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 2 syntheses or guidelines pooled it, 21 citations in OpenAlex.

  1. Pooled it
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  3. Trial
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  7. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 3 countries.

Y B SomaniDepartment of Kinesiology, Integrative Vascular Physiology Lab, Penn State University, University Park, PA, USA.ORCID 0000-0001-9905-3038
R N SoaresDalton Cardiovascular Research Center, Department of Medicine, University of Missouri, Columbia, MO, USA.ORCID 0000-0002-9877-683X
J GosaliaDepartment of Kinesiology, Integrative Vascular Physiology Lab, Penn State University, University Park, PA, USA.
J M DelgadoDepartment of Kinesiology, Integrative Vascular Physiology Lab, Penn State University, University Park, PA, USA.ORCID 0000-0002-3183-0707
M FlanaganPenn State Hershey Family and Community Medicine, University Park, PA, USA.
S BasuTranslational Science Center and Department of Physics, Wake Forest University, Winston-Salem, NC, USA.
D B Kim-ShapiroTranslational Science Center and Department of Physics, Wake Forest University, Winston-Salem, NC, USA.
J M MuriasDepartment of Kinesiology, University of Calgary, Calgary, AB, Canada.ORCID 0000-0002-6460-6453
D N ProctorDepartment of Kinesiology, Integrative Vascular Physiology Lab, Penn State University, University Park, PA, USA.
Pennsylvania State University · USVirginia Tech - Wake Forest University School of Biomedical Engineering & Sciences · USCardiovascular Research Center · BRUniversity of Calgary · CA

Funding

Storage Lesion in Banked Blood Due to Disruption of Nitric Oxide HomeostasisR01HL098032 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Mark T Gladwin · 2009 to 2026
$12.5M
Novel Therapies to Improve Cardiac and Skeletal Muscle O2 Supply-Demand Mismatch in Older Adults with Peripheral Arterial DiseaseR21AG054940 · NIA · PENNSYLVANIA STATE UNIVERSITY, THE · PI PROCTOR, DAVID N · 2018 to 2019
$429k
NHLBI NIH HHS R01 HL098032NIA NIH HHS R21 AG054940
6 · The paper itself

Abstract

The onset of menopause and accompanying changes to ovarian hormones often precedes endothelial dysfunction in women. In particular, accelerated impairments in macrovascular and microvascular function coincide with the loss of estrogen, as does impaired endothelial responses to ischemia-reperfusion (IR) injury. In healthy, early postmenopausal women (

Indexed as

NitratesReperfusion InjuryCross-Over StudiesDietary SupplementsDouble-Blind MethodEndothelium, VascularFemaleHumansNitric OxidePostmenopauseNitratesNitric Oxidecardiovascular diseasedietary nitratedysfonctionnement endothélialendothelial dysfunctionfonction vasculaireischemia−reperfusionischémie–reperfusionmaladie cardiovasculairenitrate alimentairepostmenopausalpostménopausevascular function

Identifiers

PMID35358395
PMCPMC10941101
OpenAlexW4221095373

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.