ArticleBone & joint research2022
Tibial cortex transverse transport accelerates wound healing via enhanced angiogenesis and immunomodulation.
Article in Bone & joint research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 1 of them a synthesis that pooled it.
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Who cites it
43 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.
- Effectiveness of transverse tibial bone transport in treatment of diabetic foot ulcer: A systematic review and meta-analysis.Frontiers in endocrinology · 2022Pooled it
- [Effectiveness of tibial transverse transport combined with modified neurolysis in treatment of diabetic foot ulcers].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2023Trial
- Tibial cortex transverse transport accelerates diabetic wound healing via systemic mobilization of non-classical monocytes : an animal study.Bone & joint research · 2026Article
- Bone‑origin repair in diabetic foot ulcers: Mechanisms of callus formation and endocrine effects in healing (Review).International journal of molecular medicine · 2026Review
- Efficacy of the Tibial Transverse Bone Transport Technique in the Management of Thromboangiitis Obliterans: A Systematic Review.Journal of clinical medicine · 2026Review
- Clinical Efficacy of Periosteum-Preserving Iliac Crest Transverse Transport for Symptomatic High-Level Lower Extremity Arteriosclerosis Obliterans.Chronic diseases and translational medicine · 2026Article
- Mechanotransduction and musculoskeletal regeneration: Molecular mechanisms and interdisciplinary applications.Genes & diseases · 2026Review
- Double Flap Tibial Transverse Transport Improves Microcirculation and Peripheral Nerve Function in Severe Diabetic Foot Ulcers.International wound journal · 2026Article
- Transverse tibial bone transport promotes distraction osteogenesis and improves blood flow in the management of diabetic foot.World journal of diabetes · 2026Article
- Mechanotransduction-driven macrophage polarization via Integrin-SRC-STAT6 pathway in distraction osteogenesis.Journal of orthopaedic translation · 2026Article
- Comparison of tibial cortex transverse transport and free anterolateral thigh perforator flap in the treatment of severe diabetic foot ulcers: a retrospective study.Frontiers in surgery · 2026Article
- Periosteal distraction improves blood flow and regulates inflammatory response to accelerate foot ulcer healing in diabetic rats.Journal of orthopaedic surgery and research · 2025Article
- Injured bone-triggered osteokines secretion promotes diabetic wound healing.Bone research · 2025Article
- Radial Periosteal Distraction as a Novel Intervention for Raynaud Syndrome with Gangrene: A Case Report.The American journal of case reports · 2025Article
- [Study on effectiveness and changes in immunoglobulin levels of transverse tibial transport in treatment of Wagner grade 3-4 type 2 diabetic foot ulcer].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2025Article
- A Novel Cranial Bone Transport Technique Repairs Skull Defect and Minimizes Brain Injury Outcome in Traumatic Brain Injury Rats.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Finite element analysis safety of tibial cortex transverse transport.Bone & joint research · 2025Article
- [A feasibility study of the EMO scoring system to guide proximal tibial transverse transport in treatment of diabetic foot wounds].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2025Article
- Therapeutic effects of transverse tibial bone transport in lower limb thromboangiitis obliterans.American journal of translational research · 2025Article
- A three-stage sequential surgical approach to a more efficient management of clinical stage 4 diabetic foot ulcers.Frontiers in surgery · 2025Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsTreatment for delayed wound healing resulting from peripheral vascular diseases and diabetic foot ulcers remains a challenge. A novel surgical technique named 'tibial cortex transverse transport' (TTT) has been developed for treating peripheral ischaemia, with encouraging clinical effects. However, its underlying mechanisms remain unclear. In the present study, we explored the potential biological mechanisms of TTT surgery using various techniques in a rat TTT animal model.
methodsA novel rat model of TTT was established with a designed external fixator, and effects on wound healing were investigated. Laser speckle perfusion imaging, vessel perfusion, histology, and immunohistochemistry were used to evaluate the wound healing processes.
resultsGross and histological examinations showed that TTT technique accelerated wound closure and enhanced the quality of the newly formed skin tissues. In the TTT group, haematoxylin and eosin (H&E) staining demonstrated a better epidermis and dermis recovery, while immunohistochemical staining showed that TTT technique promoted local collagen deposition. The TTT technique also benefited to angiogenesis and immunomodulation. In the TTT group, blood flow in the wound area was higher than that of other groups according to laser speckle imaging with more blood vessels observed. Enhanced neovascularization was seen in the TTT group with double immune-labelling of CD31 and α-Smooth Muscle Actin (α-SMA). The number of M2 macrophages at the wound site in the TTT group was also increased.
conclusionThe TTT technique accelerated wound healing through enhanced angiogenesis and immunomodulation. Cite this article:
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.