ArticleJournal of clinical laboratory analysis2022
Prognostic value of glucose-to-lymphocyte ratio in critically ill patients with acute respiratory distress syndrome: A retrospective cohort study.
Article in Journal of clinical laboratory analysis, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- Association between glucose to lymphocyte ratio and prognosis in patients with solid tumors.Frontiers in immunology · 2024Pooled it
- High glucose-to-lymphocyte ratio increases the risk of delirium and all-cause mortality in intensive care unit patients.Scientific reports · 2026Article
- Association between prognostic nutritional index and 28-day mortality in patients with sepsis-associated acute respiratory distress syndrome.Frontiers in nutrition · 2026Article
- Association between the glucose-to-lymphocyte ratio and prognosis in COVID-19 patients.Frontiers in cellular and infection microbiology · 2026Article
- Observational
- Association of glucose-lymphocyte ratio and short-term mortality in patients with sepsis complicated by ARDS during the acute phase: a multicenter retrospective cohort study.Frontiers in cellular and infection microbiology · 2026Observational
- Evaluating the role of glucose-to-lymphocyte ratio as a prognostic indicator in pediatric moderate to severe traumatic brain injury.European journal of medical research · 2025Article
- Association of magnesium sulphate use with mortality in patients with acute respiratory distress syndrome: a retrospective propensity score-matched cohort study.Scientific reports · 2025Article
- Association of early ondansetron use with 30-day mortality in patients with acute respiratory distress syndrome: a retrospective cohort study.Journal of thoracic disease · 2025Article
- Association Between the Glucose-to-Lymphocyte Ratio and 28-Day Mortality in Patients with Mechanical Ventilation.Balkan medical journal · 2025Article
- Association between Glucose/lymphocytes Ratio and Contrast-Induced Acute Kidney Injury in Patients with Myocardial Infarction without Diabetes Mellitus.Arquivos brasileiros de cardiologia · 2025Article
- Association between glucose-to-lymphocyte ratio and mortality in patients with heart failure from the MIMIC-IV database: a retrospective cohort study.Scientific reports · 2025Article
- Predictive value of hematologic indices on weaning from mechanical ventilation and 30-day mortality in patients with traumatic brain injury in an intensive care unit: A retrospective analysis of MIMIC-IV data.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025Article
- Early Predictive Value of the Glucose-to-Lymphocyte Ratio for the Occurrence of Stroke-Associated Pneumonia.Brain and behavior · 2025Article
- Relationship between glucose to lymphocyte ratio and the first peritonitis episode in patients treated with peritoneal dialysis.Scientific reports · 2025Article
- Association of glucose to lymphocyte ratio with the risk of death in patients with atherosclerotic cardiovascular disease.Scientific reports · 2025Article
- Association of Albumin-Bilirubin (ALBI) Grade With 28-Day All-Cause Mortality in Patients With Acute Respiratory Distress Syndrome: A Retrospective Analysis of the MIMIC-IV Database.Mediators of inflammation · 2025Article
- Article
- Effects of acetaminophen use on mortality of patients with acute respiratory distress syndrome: secondary data mining based on the MIMIC-IV database.BMC pulmonary medicine · 2024Article
- The Role of Glucose-Lymphocyte Ratio in Evaluating the Severity of Coronary Artery Disease.Journal of clinical medicine · 2024Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThere is need to identify biomarkers for prognosis of acute respiratory distress syndrome (ADRS). This may allow early and accurate identification of patients with high-risk ARDS to guide adjustment of clinical treatment and nursing intervention, which would ultimately improve prognosis of patients with ARDS. Biomarkers based on a combination of fasting glucose and lymphocyte counts to predict prognosis in critically ill patients with ARDS remain undefined. In this study, we investigated the association between glucose-to-lymphocyte ratio (GLR) and in-hospital mortality.
methodsThe study obtained data from Medical Information Mart for Intensive Care-IV (MIMIC-IV Version 1.0) database. We defined the GLR as fasting glucose/lymphocyte count and the patient in-hospital mortality was considered as the outcome. In addition, we employed linear and logistic regression models for analysis.
resultsIn total, 1,085 patients with ARDS were included in this study. The eligible participants included 498 female and 587 males, with a mean age of 64.2 ± 17.5 years. Logistic regression analysis demonstrated that higher GLR was an independent risk factor for all-cause mortality (OR =1.67, 95% CI: 1.26-2.22) after adjusting for age, sex, anion gap, white blood cell count, congestive heart failure, sequential organ failure assessment (SOFA), SBP, DBP, and respiratory rate in both the dichotomized group and subgroups. We also analyzed the in-hospital mortality to ROC curves by comparing the value between SOFA + GLR and SOFA. The area under the curve (AUC) was 0.6991 for the SOFA + GLR (95% CI: 0.6634-0.7348), and 0.6613 for the SOFA (95% CI: 0.6238-0.6988).
conclusionOur data showed that the GLR was an independent predictor of in-hospital mortality for patients with ARDS. The GLR is an integrated, readily available clinical biomarker for mortality in patients with ARDS.
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