Evidence map›Paper›PMID 35358242›Full record

ArticlePloS one2022

Multi-modality human phenotyping to examine subjective and objective health afflictions in former professional American-style football players: The In-Person Assessment (IPA) protocol.

Bryan Cortez, Chelsea Valdivia, Dylan Keating, Dean Marengi, Trevor Bates, Cheyenne Brown, Inana Dairi, Michael Doyle, Robyn Keske, Ann Connor and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Bryan CortezFootball Players Health Study at Harvard University, Harvard Medical School, Boston, Massachusetts, United States of America.ORCID 0000-0001-8746-9618
Chelsea ValdiviaFootball Players Health Study at Harvard University, Harvard Medical School, Boston, Massachusetts, United States of America.
Dylan KeatingFootball Players Health Study at Harvard University, Harvard Medical School, Boston, Massachusetts, United States of America.
Dean MarengiFootball Players Health Study at Harvard University, Harvard Medical School, Boston, Massachusetts, United States of America.
Trevor BatesFootball Players Health Study at Harvard University, Harvard Medical School, Boston, Massachusetts, United States of America.
Cheyenne BrownFootball Players Health Study at Harvard University, Harvard Medical School, Boston, Massachusetts, United States of America.
Inana DairiFootball Players Health Study at Harvard University, Harvard Medical School, Boston, Massachusetts, United States of America.
Michael DoyleFootball Players Health Study at Harvard University, Harvard Medical School, Boston, Massachusetts, United States of America.
Robyn KeskeFootball Players Health Study at Harvard University, Harvard Medical School, Boston, Massachusetts, United States of America.
Ann ConnorFootball Players Health Study at Harvard University, Harvard Medical School, Boston, Massachusetts, United States of America.
Rachel GrashowFootball Players Health Study at Harvard University, Harvard Medical School, Boston, Massachusetts, United States of America.
Adam TenfordeFootball Players Health Study at Harvard University, Harvard Medical School, Boston, Massachusetts, United States of America.
Meagan M WasfyDepartment of Internal Medicine, Cardiovascular Performance Program, Massachusetts General Hospital, Boston, Massachusetts, United States of America.
Marc G WeisskopfFootball Players Health Study at Harvard University, Harvard Medical School, Boston, Massachusetts, United States of America.
Frank SpeizerChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, United States of America.
Ross ZafonteFootball Players Health Study at Harvard University, Harvard Medical School, Boston, Massachusetts, United States of America.
Aaron BaggishFootball Players Health Study at Harvard University, Harvard Medical School, Boston, Massachusetts, United States of America.ORCID 0000-0003-2042-1489

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundParticipation in American-style football (ASF), one of the most popular sports worldwide, has been associated with adverse health outcomes. However, prior clinical studies of former ASF players have been limited by reliance on subjective self-reported data, inadequate sample size, or focus on a single disease process in isolation.

objectiveTo determine the burden of objective multi-system pathology and its relationship with subjective health complaints among former professional ASF players.

methodsThe In-Person Assessment is a case-control, multi-day, deep human phenotyping protocol designed to characterize and quantify pathology among former professional ASF players. Participants, recruited from an on-going large-scale longitudinal cohort study, will include 120 men who report either no health conditions, a single health condition, or multiple health conditions across the key domains of cardiometabolic disease, disordered sleep, chronic pain, and cognitive impairment. Data will be collected from validated questionnaires, structured interviews, physical examinations, multi-modality imaging, and functional assessments over a 3-day study period. A pilot study was conducted to assess feasibility and to obtain participant feedback which was used to shape the final protocol.

resultsThis study provides a comprehensive assessment of objective multi-system pathology and its relationship with subjective health complaints among former professional ASF players.

conclusionThe study will determine whether subjective health complaints among former professional ASF players are explained by objective explanatory pathology and will provide novel opportunities to examine the interrelatedness of co-morbidities. It is anticipated that this protocol will be applicable to other clinical and occupational populations.

Indexed as

FootballAthletesCross-Sectional StudiesHumansLongitudinal StudiesMaleMultimorbidityPilot ProjectsUnited States

Identifiers

PMID35358242
PMCPMC8970522

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.