Evidence map›Paper›PMID 35358208›Full record

Observational studyPloS one2022

Cardiovascular risk in newly diagnosed type 2 diabetes patients in India.

A G Unnikrishnan, R K Sahay, Uday Phadke, S K Sharma, Parag Shah, Rishi Shukla, Vijay Viswanathan, S K Wangnoo, Santosh Singhal, Mathew John and 5 more

Abstract readObservational Study
In one paragraph

Observational study in PloS one, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Identifying Drug Prescription in Newly Diagnosed Hypertension Patients in India.Journal of clinical hypertension (Greenwich, Conn.) · 2025
    Observational
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

A G UnnikrishnanChellaram Diabetes Institute, Pune, India.
R K SahayDepartment of Endocrinology, Osmania Medical College, Osmania General Hospital, Hyderabad, India.
Uday PhadkeSahyadri Hospital, Erandwane, Pune, Maharashtra, India.
S K SharmaGalaxy Speciality Centre, Jaipur, Rajasthan, India.
Parag ShahGujarat Endocrine Centre, Ahmedabad, Gujarat, India.
Rishi ShuklaDr Rishi Shukla Centre for Diabetes & Endocrine Diseases, Kanpur, Uttar Pradesh, India.
Vijay ViswanathanMV Hospital for Diabetes, Chennai, Tamilnadu, India.
S K WangnooIndraprashth Apollo Hospital, New Delhi, India.
Santosh SinghalDirector, Sparsh Health Care & CHS Apple Hospital, Gwalior, Madhya Pradesh, India.
Mathew JohnProvidence Endocrine and Diabetes Specialty Centre, Trivandrum, India.
Ajay KumarDiabetes Care & Research Centre, Patna, Bihar, India.
Mala DharmalingamBangalore Endocrinology & Centre, Bangalore, Karnataka, India.
Subodh JainDiabetes Care Centre, Prayagraj, Uttar Pradesh, India.
Shehla ShaikhKGN Diabetes & Endocrinology Centre, Nagpada, Mumbai, Maharashtra, India.
Willem J VerberkCARIM School for Cardiovascular Diseases, Maastricht University, Maastricht, the Netherlands.ORCID 0000-0003-2230-0488

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundType 2 diabetes mellitus (T2DM) worldwide continues to increase, in particular in India. Early T2DM diagnosis followed by appropriate management will result in more cardiovascular event free life years. However, knowledge of the cardiovascular profile of newly diagnosed T2DM patients is still limited. The aim of this study was to understand the extent of cardiovascular disease (CVD) risk of newly diagnosed T2DM patients in India.

methodsA cross sectional observational study was conducted to evaluate clinical laboratory and socio-demographic parameters of 5,080 newly diagnosed T2DM patients (48.3 ± 12.8 years of age; 36.7% female). In addition, we determined their cardiovascular risk according to the guidelines of the Lipid Association of India (LAI) and the criteria of the QRISK3 score.

resultsOf the newly T2DM diagnosed patients in India 2,007(39.5%) were classified as "High risk" and 3,073 (60.5%) were classified as "Very high risk" based on LAI criteria. On average, patients had 1.7 ± 0.9 major atherosclerotic cardiovascular disease (ASCVD) risk factors. Low HDL-C value was the most frequent major risk (2,823; 55.6%) followed by high age (2,502; 49.3%), hypertension (2,141; 42.1%), smoking/tobacco use (1,078; 21.2%) and chronic kidney disease stage 3b or higher (568; 11.2%). In addition, 4,192 (82.5%) patients appeared to have at least one cholesterol abnormality and, if the latest LAI recommendations are applied, 96.5% (4,902) presented with lipid values above recommended targets. Based on the QRISK3 calculation Indian diabetes patients had an average CVD risk of 15.3 ± 12.3%, (12.2 ± 10.1 vs. 17.1 ± 13.5 [p<0.001] for females and males, respectively).

conclusionsNewly diagnosed Indian T2DM patients are at high ASCVD risk. Our data therefore support the notion that further extension of nationwide ASCVD risk identification programs and prevention strategies to reduce the occurrence of cardiovascular diseases are warranted.

Indexed as

AtherosclerosisCardiovascular DiseasesDiabetes Mellitus, Type 2AdultCross-Sectional StudiesFemaleHeart Disease Risk FactorsHumansIndiaLipidsMaleRisk FactorsLipids

Identifiers

PMID35358208
PMCPMC8970505

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.