Evidence map›Paper›PMID 35358177›Full record

ArticlePLoS biology2022

The effect of apathy and compulsivity on planning and stopping in sequential decision-making.

Jacqueline Scholl, Hailey A Trier, Matthew F S Rushworth, Nils Kolling

Abstract read
In one paragraph

Article in PLoS biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Article
  2. On the relationships between apathy, depression and anhedonia.Journal of neurology, neurosurgery, and psychiatry · 2026
    Article
  3. Article
  4. Decision context and neurobehavioural disturbance in Huntington's disease.Cognitive, affective & behavioral neuroscience · 2026
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Is Apathy a New Risk Factor for Adverse Health Outcomes Among Older Adults With CKD?American journal of kidney diseases : the official journal of the National Kidney Foundation · 2024
    Article
  14. Article
  15. Review
  16. Reflecting on 2022.PLoS biology · 2022
    Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jacqueline SchollLyon Neuroscience Research Center, INSERM U1028, CNRS UMR5292, PSYR2 Team, University Lyon 1, Lyon, France.ORCID 0000-0001-9969-1355
Hailey A TrierWellcome Integrative Neuroimaging (WIN), Department of Experimental Psychology, University of Oxford, Oxford, United Kingdom.ORCID 0000-0003-2064-0614
Matthew F S RushworthWellcome Integrative Neuroimaging (WIN), Department of Experimental Psychology, University of Oxford, Oxford, United Kingdom.ORCID 0000-0002-5578-9884
Nils KollingOxford Centre of Human Brain Activity, Wellcome Integrative Neuroimaging (WIN), Department of Psychiatry, University of Oxford, Oxford, United Kingdom.ORCID 0000-0002-0283-6966

Funding

Biotechnology and Biological Sciences Research Council BB/R010803/1Biotechnology and Biological Sciences Research Council BB/R01803/1Biotechnology and Biological Sciences Research Council BB/V004999/1Medical Research Council G0902373Medical Research Council MR/N014448/1Wellcome Trust 203139/Z/16/ZWellcome Trust WT100973AIA
6 · The paper itself

Abstract

Real-life decision-making often comprises sequences of successive decisions about whether to take opportunities as they are encountered or keep searching for better ones instead. We investigated individual differences related to such sequential decision-making and link them especially to apathy and compulsivity in a large online sample (discovery sample: n = 449 and confirmation sample: n = 756). Our cognitive model revealed distinct changes in the way participants evaluated their environments and planned their own future behaviour. Apathy was linked to decision inertia, i.e., automatically persisting with a sequence of searches for longer than appropriate given the value of searching. Thus, despite being less motivated, they did not avoid the effort associated with longer searches. In contrast, compulsivity was linked to self-reported insensitivity to the cost of continuing with a sequence of searches. The objective measures of behavioural cost insensitivity were clearly linked to compulsivity only in the discovery sample. While the confirmation sample showed a similar effect, it did not reach significance. Nevertheless, in both samples, participants reported awareness of such bias (experienced as "overchasing"). In addition, this awareness made them report preemptively avoiding situations related to the bias. However, we found no evidence of them actually preempting more in the task, which might mean a misalignment of their metacognitive beliefs or that our behavioural measures were incomplete. In summary, individual variation in distinct, fundamental aspects of sequential decision-making can be linked to variation in 2 measures of behavioural traits associated with psychological illness in the normal population.

Indexed as

ApathyMetacognitionDecision MakingHumans

Identifiers

PMID35358177
PMCPMC8970514

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.