ArticleProceedings of the National Academy of Sciences of the United States of America2022
Optimal deep brain stimulation sites and networks for cervical vs. generalized dystonia.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers, 1 of them a synthesis that pooled it.
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Who cites it
58 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Clinical efficacy of neuromodulation in isolated dystonia: A systematic review of motor function improvement.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Pooled it
- Bed nucleus of the stria terminalis-nucleus accumbens stimulation for depression: A randomized, double-blind, crossover trial.Cell reports. Medicine · 2026Trial
- Linking Invasive and Noninvasive Brain Stimulation in Parkinson's Disease: A Randomized Trial.Movement disorders : official journal of the Movement Disorder Society · 2024Trial
- Connectivity Profile for Subthalamic Nucleus Deep Brain Stimulation in Early Stage Parkinson Disease.Annals of neurology · 2023Trial
- Distinct Brain Drivers and Shared Cerebello-Cortical Input in ADCY5 and SGCE Hyperkinetic Movements.Movement disorders : official journal of the Movement Disorder Society · 2026Article
- Next-Generation Neuromodulation for Anxiety: Circuit-Based and Personalized Approaches.Current psychiatry reports · 2026Review
- Subthalamic segmentations in relation to deep brain stimulation volumes in Parkinson's disease.Acta neurochirurgica · 2026Article
- Direct electrical stimulation of the human amygdala enhances recognition memory for objects but not scenes.Communications biology · 2026Article
- Probabilistic Lesion Mapping to Optimize Thalamotomy Targets for Focal Hand Dystonia.Annals of neurology · 2026Article
- Simultaneous pallidal and centromedian deep brain stimulation for combined dystonia and drug-resistant epilepsy in a child with hypoxic-ischemic encephalopathy: a technical case report.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2026Article
- The optimization of neuroprosthetic interfaces relying on biophysical and surrogate digital twins.npj biomedical innovations · 2026Review
- Functional Connectivity to the Cerebellum and Resting-State Networks Predict Earlier Improvement of Dystonia Following Globus Pallidus Internus-Deep Brain Stimulation (GPi-DBS).Movement disorders : official journal of the Movement Disorder Society · 2026Article
- Optimal Deep Brain Stimulation Locations for Gilles de la Tourette Syndrome.medRxiv : the preprint server for health sciences · 2026Article
- Spatial signature of low-frequency network changes accounts for pallidal stimulation outcome in cervical dystonia.EBioMedicine · 2026Article
- Cross-species lesion mapping links a midbrain circuit to vergence dysfunction.Brain : a journal of neurology · 2026Article
- Optimal Stimulation Sites and Long-Term Efficacy of Pallidal Deep-Brain Stimulation for Patients With Tardive Dystonia.Journal of movement disorders · 2026Article
- Thalamic Deep Brain Stimulation for Dystonic Head Tremor: A Long-Term Study of 18 Patients.Movement disorders clinical practice · 2026Article
- Cerebellar motor and non-motor contributions to dystonia pathophysiology and treatment.Dystonia (Lausanne, Switzerland) · 2026Article
- Hyperdirect projections from the supplementary motor area mediate subthalamic stimulation effects on movement initiation and inhibition in Parkinson's disease.Brain communications · 2026Article
- A Multi-Symptom Circuit Architecture of Obsessive-Compulsive Disorder.medRxiv : the preprint server for health sciences · 2025Article
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Authors and funding
25 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Dystonia is a debilitating disease with few treatment options. One effective option is deep brain stimulation (DBS) to the internal pallidum. While cervical and generalized forms of isolated dystonia have been targeted with a common approach to the posterior third of the nucleus, large-scale investigations regarding optimal stimulation sites and potential network effects have not been carried out. Here, we retrospectively studied clinical results following DBS for cervical and generalized dystonia in a multicenter cohort of 80 patients. We model DBS electrode placement based on pre- and postoperative imaging and introduce an approach to map optimal stimulation sites to anatomical space. Second, we investigate which tracts account for optimal clinical improvements, when modulated. Third, we investigate distributed stimulation effects on a whole-brain functional connectome level. Our results show marked differences of optimal stimulation sites that map to the somatotopic structure of the internal pallidum. While modulation of the striatopallidofugal axis of the basal ganglia accounted for optimal treatment of cervical dystonia, modulation of pallidothalamic bundles did so in generalized dystonia. Finally, we show a common multisynaptic network substrate for both phenotypes in the form of connectivity to the cerebellum and somatomotor cortex. Our results suggest a brief divergence of optimal stimulation networks for cervical vs. generalized dystonia within the pallidothalamic loop that merge again on a thalamo-cortical level and share a common whole-brain network.
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