ArticleEpilepsia open2022
Scalp HFO rates are higher for larger lesions.
Article in Epilepsia open, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 22 citations in OpenAlex.
- Scalp high-frequency activity differentiates neonates with seizures from healthy neonates and indicates postneonatal epilepsy risk.Epilepsia · 2026Article
- High-frequency oscillations >250 Hz in people with Down syndrome and associated Alzheimer's disease dementia.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Article
- The appearance of scalp high-frequency oscillations is associated with poor seizure control in pediatric epilepsy patients.Epilepsia open · 2025Article
- Interictal EEG spikes increase perfusion in low-grade epilepsy-associated tumors: a pediatric arterial spin labeling study.La Radiologia medica · 2025Article
- High-frequency oscillations in scalp EEG lateralize to the epileptogenic hemisphere in children and adults.Clinical neurophysiology practice · 2025Article
- Lesion volume and spike frequency on EEG impact perfusion values in focal cortical dysplasia: a pediatric arterial spin labeling study.Scientific reports · 2024Article
- Scalp high-frequency oscillations differentiate neonates with seizures from healthy neonates.Epilepsia open · 2023Article
- Passive and active markers of cortical excitability in epilepsy.Epilepsia · 2023Review
- High-frequency oscillations (250-500 Hz) in animal models of Alzheimer's disease and two animal models of epilepsy.Epilepsia · 2023Article
- Scalp HFO rates are higher for larger lesions.Epilepsia open · 2022Article
- Automatic Detection of High-Frequency Oscillations With Neuromorphic Spiking Neural Networks.Frontiers in neuroscience · 2022Review
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
High-frequency oscillations (HFO) in scalp EEG are a new and promising noninvasive epilepsy biomarker, providing added prognostic value, particularly in pediatric lesional epilepsy. However, it is unclear if lesion characteristics, such as lesion volume, depth, type, and localization, impact scalp HFO rates. We analyzed scalp EEG from 13 children and adolescents with focal epilepsy associated with focal cortical dysplasia (FCD), low-grade tumors, or hippocampal sclerosis. We applied a validated automated detector to determine HFO rates in bipolar channels. We identified the lesion characteristics in MRI. Larger lesions defined by MRI volumetric analysis corresponded to higher cumulative scalp HFO rates (P = .01) that were detectable in a higher number of channels (P = .05). Both superficial and deep lesions generated HFO detectable in the scalp EEG. Lesion type (FCD vs tumor) and lobar localization (temporal vs extratemporal) did not affect scalp HFO rates in our study. Our observations support that all lesions may generate HFO detectable in scalp EEG, irrespective of their characteristics, whereas larger epileptogenic lesions generate higher scalp HFO rates over larger areas that are thus more accessible to detection. Our study provides crucial insight into scalp HFO detectability in pediatric lesional epilepsy, facilitating their implementation as an epilepsy biomarker in a clinical setting.
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