Evidence map›Paper›PMID 35357694›Full record

ArticleJournal of the American Geriatrics Society2022

Life expectancy for community-dwelling persons with dementia and severe disability.

Krista L Harrison, Christine S Ritchie, Lauren J Hunt, Kanan Patel, W John Boscardin, Kristine Yaffe, Alexander K Smith

Abstract read
In one paragraph

Article in Journal of the American Geriatrics Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Review
  5. Article
  6. Incomplete Ascertainment of Mortality in a Nationally Representative Longitudinal Study of Community-Living Older Americans.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025
    Article
  7. Article
  8. Article
  9. Anticipatory Guidance in Dementia Across the Stages #455.Journal of palliative medicine · 2023
    Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Krista L HarrisonDivision of Geriatrics, Department of Medicine, University of California San Francisco, San Francisco, California, USA.ORCID 0000-0001-5373-3011
Christine S RitchieDivision of Geriatrics, Department of Medicine, University of California San Francisco, San Francisco, California, USA.
Lauren J HuntGlobal Brain Health Institute, University of California San Francisco, San Francisco, California, USA.ORCID 0000-0002-2731-2173
Kanan PatelDivision of Geriatrics, Department of Medicine, University of California San Francisco, San Francisco, California, USA.
W John BoscardinDivision of Geriatrics, Department of Medicine, University of California San Francisco, San Francisco, California, USA.
Kristine YaffeGlobal Brain Health Institute, University of California San Francisco, San Francisco, California, USA.
Alexander K SmithDivision of Geriatrics, Department of Medicine, University of California San Francisco, San Francisco, California, USA.

Funding

Residing in the Community with Dementia at the End of Life: Understanding Hospice Use and Residential SettingP30AG028741 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI ORNA INTRATOR · 2010 to 2026
$21.9M
VARC CoreP30AG044281 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Louise C. Walter · 2013 to 2026
$19.9M
Institutional Career Development Core SupplementKL2TR001870 · NCATS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KANAYA, ALKA M., SARKAR, URMIMALA · 2016 to 2025
$19.7M
Unnecessary and Harmful Medication Use in Older Adults with DementiaP01AG066605 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KENNETH E. COVINSKY, R. Sean Morrison · 2020 to 2026
$17.7M
Population Based Research for Alzheimer's Innovation (POP BRAIN)R35AG071916 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI YAFFE, KRISTINE · 2021 to 2024
$3.8M
Prognostic calculators for patients with Alzheimers disease and related dementiasR01AG057751 · NIA · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · PI LEE, SEI, SMITH, ALEXANDER KELIIMOEANU · 2018 to 2021
$1.5M
Predictors & Outcomes of Cognitive Trajectories in the Oldest OldK24AG031155 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI YAFFE, KRISTINE · 2007 to 2020
$1.5M
Mentoring Researchers in Prognosis Research in Alzheimer’s Disease and Related DementiasK24AG068312 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Alexander Keliimoeanu Smith · 2020 to 2026
$1.2M
Hospice Use in Older Adults with Alzheimer's Disease and Related Dementias: Patterns, Policies, and Caregiver ExperiencesK76AG074924 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HUNT, LAUREN · 2021 to 2025
$1.1M
Palliative Care for People Living at Home with Advancing Dementia and Their CaregiversK01AG059831 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HARRISON, KRISTA LYN · 2019 to 2023
$720k
NCATS NIH HHS KL2 TR001870NCATS NIH HHS KL2TR001870NIA NIH HHS 3P30AG044281-08S1NIA NIH HHS K01 AG059831NIA NIH HHS K01AG059831NIA NIH HHS K24 AG031155NIA NIH HHS K24AG031155NIA NIH HHS K24 AG068312NIA NIH HHS K24AG068312NIA NIH HHS K76 AG074924NIA NIH HHS L30 AG060590NIA NIH HHS P01 AG066605NIA NIH HHS P01AG066605NIA NIH HHS P30 AG028741NIA NIH HHS P30 AG044281NIA NIH HHS P30AG044281NIA NIH HHS R01 AG057751NIA NIH HHS R01AG0577513NIA NIH HHS R35 AG071916
6 · The paper itself

Abstract

backgroundUnderstanding life expectancy can help persons with dementia, their care partners, and policymakers plan for what lies ahead. We sought to determine life expectancy and predictors of mortality for community-dwelling persons with dementia and severe disability.

methodsUsing the National Health and Aging Trends Study (NHATS) linked to Medicare claims, we identified community-dwelling respondents age 65+ who entered NHATS in 2011 with dementia and severe disability (defined as three impairments in activities of daily living), or who subsequently met criteria for dementia and then severe disability. We estimated time to death based on the timing of meeting severe disability criteria. We conducted parametric survival analyses using a Gompertz distribution to calculate risk of death and predicted median time to death. Predictors included demographic, functional, clinical characteristics, and behavioral symptoms (assessed among NHATS respondents with proxy interviews).

resultsAmong 842 community-dwelling persons with dementia and severe disability, 80.5% died during the study period. After adjusting for age and gender, overall predicted median time to death was 1.7 years (25th percentile 0.6, 75th percentile 3.8 years). Six notable characteristics were associated with shorter life expectancy: 1) older age (90+), with a predicted median time to death of 1.0 year (0.4, 2.1); 2) being bedbound, 1.1 years (0.4, 2.3); 3) being homebound, 1.2 years (0.5, 2.6); 4) having comorbid cancer, 1.2 years (0.5, 2.6); 5) unintended weight loss, 1.4 years (0.5, 3.1); and 6) comorbid depression, 1.5 years (0.6, 3.3).

conclusionsCommunity-dwelling persons with dementia and severe disability lived a median of 1.7 years. Clinicians can use the study findings to provide anticipatory guidance to patients and care partners, and policymakers to inform design of longitudinal supportive services.

Indexed as

DementiaPersons with DisabilitiesActivities of Daily LivingAgedHumansIndependent LivingLife ExpectancyMedicareUnited Statescommunitydementialife expectancymortalityprognosis

Identifiers

PMID35357694
PMCPMC9177709

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.