Evidence map›Paper›PMID 35357594›Full record

ArticleJournal of molecular modeling2022

Investigation of the structural dynamics of a knotted protein and its unknotted analog using molecular dynamics.

José Cícero Alves Silva, Elton José Ferreira Chaves, Gabriel Aires Urquiza de Carvalho, Gerd Bruno Rocha

Abstract read
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In one paragraph

Article in Journal of molecular modeling, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

José Cícero Alves SilvaDepartment of Chemistry, Federal University of Paraíba, Cidade Universitária, Joao Pessoa, PB, 58051-900, Brazil.
Elton José Ferreira ChavesDepartment of Biotechnology, Federal University of Paraíba, Cidade Universitária, Joao Pessoa, PB, 58051-900, Brazil.
Gabriel Aires Urquiza de CarvalhoFundamental Department of Chemistry, Federal University of Pernambuco, Cidade Universitária, Recife, PE, 50670-901, Brazil.
Gerd Bruno RochaDepartment of Chemistry, Federal University of Paraíba, Cidade Universitária, Joao Pessoa, PB, 58051-900, Brazil. gbr@quimica.ufpb.br.ORCID http://orcid.org/0000-0001-9805-9497

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 309761/2017-4Coordenação de Aperfeiçoamento de Pessoal de Nível Superior AUXPE1375/2014
6 · The paper itself

Abstract

The role of knots in proteins remains elusive. Some studies suggest an impact on stability; the difficulty in comparing systems to assess this effect, however, has been a significant challenge. In this study, we produced and analyzed molecular dynamic trajectories considering three different temperatures of two variants of ornithine transcarbamylase (OTC), only one of which has a 3

Indexed as

Molecular Dynamics SimulationProteinsProtein ConformationProteinsDCCMKnotted proteinsMolecular dynamicsPCAStability

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.