ArticleEuropean radiology2022
Increased regional ventilation as early imaging marker for future disease progression of interstitial lung disease: a feasibility study.
Article in European radiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 11 citations in OpenAlex.
- CT-based lung ventilation metrics: reference ranges and pulmonary function test correlations in healthy individuals.European radiology · 2026Article
- Assessment of CT quantitative characteristics derived from CT in connective tissue disease-associated interstitial lung disease.Journal of thoracic disease · 2026Article
- Investigating the impact of key algorithm parameters and patient-specific factors on the accuracy of CT ventilation imaging.Journal of applied clinical medical physics · 2026Article
- Extent of alveolar collapse in expiratory CT as a prognostic marker in idiopathic pulmonary fibrosis.PloS one · 2026Article
- Future Applications of Cardiothoracic CT.Radiology · 2025Review
- More accessible functional lung imaging: non-contrast CT-ventilation demonstrates strong association and agreement with PET-ventilation.Respiratory research · 2025Article
- Acinar micromechanics in health and lung injury: what we have learned from quantitative morphology.Frontiers in physiology · 2023Review
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesIdiopathic pulmonary fibrosis (IPF) is a disease with a poor prognosis and a highly variable course. Pathologically increased ventilation-accessible by functional CT-is discussed as a potential predecessor of lung fibrosis. The purpose of this feasibility study was to investigate whether increased regional ventilation at baseline CT and morphological changes in the follow-up CT suggestive for fibrosis indeed occur in spatial correspondence.
methodsIn this retrospective study, CT scans were performed at two time points between September 2016 and November 2020. Baseline ventilation was divided into four categories ranging from low, normal to moderately, and severely increased (C1-C4). Correlation between baseline ventilation and volume and density change at follow-up was investigated in corresponding voxels. The significance of the difference of density and volume change per ventilation category was assessed using paired t-tests with a significance level of p ≤ 0.05. The analysis was performed separately for normal (NAA) and high attenuation areas (HAA).
resultsThe study group consisted of 41 patients (73 ± 10 years, 36 men). In both NAA and HAA, significant increases of density and loss of volume were seen in areas of severely increased ventilation (C4) at baseline compared to areas of normal ventilation (C2, p < 0.001). In HAA, morphological changes were more heterogeneous compared to NAA.
conclusionFunctional CT assessing the extent and distribution of lung parenchyma with pathologically increased ventilation may serve as an imaging marker to prospectively identify lung parenchyma at risk for developing fibrosis. KEY POINTS: • Voxelwise correlation of serial CT scans suggests spatial correspondence between increased ventilation at baseline and structural changes at follow-up. • Regional assessment of pathologically increased ventilation at baseline has the potential to prospectively identify tissue at risk for developing fibrosis. • Presence and extent of pathologically increased ventilation may serve as an early imaging marker of disease activity.
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