Evidence map›Paper›PMID 35357255›Full record

ArticleThe journal of histochemistry and cytochemistry : official journal of the Histochemistry Society2022

Immunohistochemical Expression of VDR in Myocardium: Postmortem Evaluation of COVID-19 Patients.

Maxim A Kriventsov, Yulianna A Yermola, Alexandra A Davydova, Alexey A Beketov, Tatyana P Makalish, Evgeniya Yu Zyablitskaya, Alina V Geraschenko, Anatoly V Kubyshkin, Anna A Galyshevskaya, Anastasia I Zausalina

Open access · bronzeAbstract read
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In one paragraph

Article in The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 96% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Maxim A KriventsovDepartment of Pathomorphology, Medical Academy named after S.I. Georgievsky, V.I. Vernadsky Crimean Federal University, Simferopol, Russia.ORCID 0000-0001-5193-4311
Yulianna A YermolaDepartment of Pathomorphology, Medical Academy named after S.I. Georgievsky, V.I. Vernadsky Crimean Federal University, Simferopol, Russia.
Alexandra A DavydovaDepartment of Pathomorphology, Medical Academy named after S.I. Georgievsky, V.I. Vernadsky Crimean Federal University, Simferopol, Russia.
Alexey A BeketovDepartment of Pathomorphology, Medical Academy named after S.I. Georgievsky, V.I. Vernadsky Crimean Federal University, Simferopol, Russia.ORCID 0000-0002-0369-5165
Tatyana P MakalishCentral Research Laboratory, Medical Academy named after S.I. Georgievsky, V.I. Vernadsky Crimean Federal University, Simferopol, Russia.
Evgeniya Yu ZyablitskayaCentral Research Laboratory, Medical Academy named after S.I. Georgievsky, V.I. Vernadsky Crimean Federal University, Simferopol, Russia.
Alina V GeraschenkoCentral Research Laboratory, Medical Academy named after S.I. Georgievsky, V.I. Vernadsky Crimean Federal University, Simferopol, Russia.
Anatoly V KubyshkinDepartment of Pathophysiology, Medical Academy named after S.I. Georgievsky, V.I. Vernadsky Crimean Federal University, Simferopol, Russia.
Anna A GalyshevskayaDepartment of Pathomorphology, Medical Academy named after S.I. Georgievsky, V.I. Vernadsky Crimean Federal University, Simferopol, Russia.
Anastasia I ZausalinaDepartment of Pathomorphology, Medical Academy named after S.I. Georgievsky, V.I. Vernadsky Crimean Federal University, Simferopol, Russia.
Research Institute of Agriculture of Crimea · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Morphological data on heart damage and its mechanisms due to extremely severe course of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection are limited, as well as data on the correlation of damage and expression of vitamin D receptors (VDRs). In this study, we analyzed a series of myocardial samples obtained during postmortem autopsy of 48 critically ill patients with COVID-19 who died with SARS-CoV-2-associated pneumonia. The purpose of the study was to evaluate immunohistochemical VDR expression in the myocardium. The results showed the only minimal or no immunohistochemical expression of VDR in the nuclei of cardiomyocytes in most cases, along with the persisted strong expression in lymphoid cells. To the best of our knowledge, it is the first study and data provided were regarding myocardial VDR expression in COVID-19 patients. The results are of interest in terms of further study of the effects of ligand-associated VDR activation on the cardiovascular system.

Indexed as

COVID-19AutopsyHumansMyocardiumMyocytes, CardiacReceptors, CalcitriolSARS-CoV-2Receptors, CalcitriolVDR protein, humanmyocardiumSARS-CoV-2vitamin D receptor

Identifiers

PMID35357255
PMCPMC9058373
OpenAlexW4221125981

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.